PRRX2 (paired related homeobox 2)

2005-10-01   Carine Gervais 

Laboratoire dHématologie et de Cytogénétique Onco-Hématologique, CHU de Hautepierre, Avenue Moliöre - BP 49, 67098 Strasbourg cedex, France

Identity

HGNC
PRRX2
LOCATION
9q34.11
LOCUSID
51450
ALIAS
PMX2,PRX2
FUSION GENES
Show Gene Fusions

DNA/RNA

Description

57 kb, 4 exons

Transcription

1327 bp mRNA

Proteins

Note

Paired mesoderm homeobox protein 2, Paired related homeobox protein 2
Atlas Image
PRRX2 protein. HD = Homeodomain.

Description

253 amino acids, 27 kDa, contains an homeobox DNA-binding domain and an OAR domain.

Expression

In embryon, higher levels of transcripts in heart, kidney, lung and skeletal muscle; lower levels in spleen and thymus ; barely detecteble levels in brain and liver.
In adult, higher levels in heart, lung, placenta and pancreas ; moderate expression in kidney and skeletal muscle.

Localisation

Nuclear

Function

Fetal skin development, cutaneous regeneration and possible role in cellular proliferation. Transcription factor activity.

Homology

Member of the paired family of homeobox proteins.
Murine Prrx2.

Implicated in

Entity name
t(9;11)(q34;p15) / t-AML --> NUP98-PRRX2
Disease
one case of adult t-AML
Cytogenetics
no additional cytogenetic abnormality in this case
Hybrid gene
5 NUP98   3 PRRX2
Atlas Image
NUP98-PRRX2 fusion cDNA partial sequence.
Fusion protein
fuses the GLFG repeat domains of NUP98 to the homeodomain of PRRX2
Atlas Image
Structure of the predicted chimeric NUP98-PRRX2 protein. FG = Phe-Gly repeats, GLEBS = RAE1 binding domain, HD = homeodomain.

Bibliography

Pubmed IDLast YearTitleAuthors
154969702005A new translocation t(9;11)(q34;p15) fuses NUP98 to a novel homeobox partner gene, PRRX2, in a therapy-related acute myeloid leukemia.Gervais C et al
116814082001NUP98 gene fusions in hematologic malignancies.Lam DH et al
103977411999NUP98 is fused to PMX1 homeobox gene in human acute myelogenous leukemia with chromosome translocation t(1;11)(q23;p15).Nakamura T et al
110632572000Human PRRX1 and PRRX2 genes: cloning, expression, genomic localization, and exclusion as disease genes for Nager syndrome.Norris RA et al
96653871998Modulation of the human homeobox genes PRX-2 and HOXB13 in scarless fetal wounds.Stelnicki EJ et al
125352102003Deletion of the homeobox gene PRX-2 affects fetal but not adult fibroblast wound healing responses.White P et al

Other Information

Locus ID:

NCBI: 51450
MIM: 604675
HGNC: 21338
Ensembl: ENSG00000167157

Variants:

dbSNP: 51450
ClinVar: 51450
TCGA: ENSG00000167157
COSMIC: PRRX2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000167157ENST00000372469Q99811
ENSG00000167157ENST00000372469A0A140VJS2

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
213858672011Model for the exceptional reactivity of peroxiredoxins 2 and 3 with hydrogen peroxide: a kinetic and computational study.40
206348912010Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.18
268242262016PRRX2 as a novel TGF-β-induced factor enhances invasion and migration in mammary epithelial cell and correlates with poor prognosis in breast cancer.10
179642822007Oxidation of Prx2 and phosphorylation of GRP58 by angiotensin II in human coronary smooth muscle cells identified by 2D-DIGE analysis.4
118937182002Regulation of vascular smooth muscle cell growth and adhesion by paired-related homeobox genes.2
314711042019Inhibition of PRRX2 suppressed colon cancer liver metastasis via inactivation of Wnt/β-catenin signaling pathway.0
322341712020[Effects of Prrx2 gene silencing on the proliferation of breast cancer and its molecular mechanisms].0

Citation

Carine Gervais

PRRX2 (paired related homeobox 2)

Atlas Genet Cytogenet Oncol Haematol. 2005-10-01

Online version: http://atlasgeneticsoncology.org/gene/42897/prrx2