RELB (v-rel reticuloendotheliosis viral oncogene homolog B)

2002-01-01   Fei Chen 

Health Effects Laboratory Division, NIOSH, 1095 Willowdale Rd, Morgantown, WV 26505, USA

Identity

HGNC
LOCATION
19q13.32
LOCUSID
ALIAS
I-REL,IMD53,IREL,REL-B
FUSION GENES

DNA/RNA

Description

The gene encoding human RelB has 11 exons spanning ~ 37 kb. Analysis of the 5-flanking region of human relb gene indicates that RelB transcription is dependent on a TATA-less promoter containing two kB sites. Thus, while relA is constitutively expressed, the expression of both rel and relb is in an inducible fashion and dependent on NF-kB.

Proteins

Expression

wide.

Localisation

cytosol, nuclei after activation.

Function

regulation of the genes involved in cell-to-cell interaction, intercellular communication, cell recruitment or transmigration, amplification or spreading of primary pathogenic signals, cell apoptosis, and initiation or acceleration of tumorigenesis. Interaction with: members of IkB family and Rel family.

Implicated in

Entity name
cancer, autoimmune arthritis, glomerulonephritis, asthma, inflammatory bowel disease, septic shock, lung fibrosis, HTLV-1 infection, and AIDS.

Bibliography

Pubmed IDLast YearTitleAuthors
87175281996The NF-kappa B and I kappa B proteins: new discoveries and insights.Baldwin AS Jr et al
81835651994Human RelB (I-Rel) functions as a kappa B site-dependent transactivating member of the family of Rel-related proteins.Bours V et al
95971301998NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses.Ghosh S et al
15772701992I-Rel: a novel rel-related protein that inhibits NF-kappa B transcriptional activity.Ruben SM et al

Other Information

Locus ID:

NCBI: 5971
MIM: 604758
HGNC: 9956
Ensembl: ENSG00000104856

Variants:

dbSNP: 5971
ClinVar: 5971
TCGA: ENSG00000104856
COSMIC: RELB

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000104856ENST00000221452Q01201
ENSG00000104856ENST00000505236D6R992
ENSG00000104856ENST00000509480D6RIV7
ENSG00000104856ENST00000589972K7ERX9
ENSG00000104856ENST00000625761Q01201

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
MAPK signaling pathwayKEGGhsa04010
Osteoclast differentiationKEGGko04380
Osteoclast differentiationKEGGhsa04380
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
Epstein-Barr virus infectionKEGGhsa05169
Epstein-Barr virus infectionKEGGko05169
NF-kappa B signaling pathwayKEGGhsa04064
NF-kappa B signaling pathwayKEGGko04064
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
C-type lectin receptors (CLRs)REACTOMER-HSA-5621481
CLEC7A (Dectin-1) signalingREACTOMER-HSA-5607764
Dectin-1 mediated noncanonical NF-kB signalingREACTOMER-HSA-5607761
CD209 (DC-SIGN) signalingREACTOMER-HSA-5621575
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
TNFR2 non-canonical NF-kB pathwayREACTOMER-HSA-5668541
NIK-->noncanonical NF-kB signalingREACTOMER-HSA-5676590

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA33678PPP3CAGenePathwayassociated23922006
PA33679PPP3CBGenePathwayassociated23922006
PA33680PPP3CCGenePathwayassociated23922006
PA33681PPP3R1GenePathwayassociated23922006
PA33682PPP3R2GenePathwayassociated23922006

References

Pubmed IDYearTitleCitations
178233042007RelB, a new partner of aryl hydrocarbon receptor-mediated transcription.109
128209692003Modulation of NF-kappaB activity by exchange of dimers.102
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
196901692009The NF-kappaB factor RelB and histone H3 lysine methyltransferase G9a directly interact to generate epigenetic silencing in endotoxin tolerance.83
218732352011Malt1-dependent RelB cleavage promotes canonical NF-kappaB activation in lymphocytes and lymphoma cell lines.76
205646282010Nuclear factor kappaB transcription factors are coexpressed and convey a poor outcome in ovarian cancer.63
169513722006Induction of RelB participates in endotoxin tolerance.55
250638732014Noncanonical NF-κB activation mediates STAT3-stimulated IDO upregulation in myeloid-derived suppressor cells in breast cancer.47
162611622006RelB regulates manganese superoxide dismutase gene and resistance to ionizing radiation of prostate cancer cells.46
179005302007Involvement of RelB in aryl hydrocarbon receptor-mediated induction of chemokines.39

Citation

Fei Chen

RELB (v-rel reticuloendotheliosis viral oncogene homolog B)

Atlas Genet Cytogenet Oncol Haematol. 2002-01-01

Online version: http://atlasgeneticsoncology.org/gene/324/relb