TAL1 (T-cell acute leukemia 1)

1998-03-01 Marie-Claude Labastie , Jean-Loup Huret Affiliation

Institut dEmbryologie Cellulaire et Moléculaire, CNRS FRE 216O, 94736, Nogent-sur-Marne Cedex, France

Identity

HGNC

TAL1

LOCATION

1p33

LOCUSID

6886

ALIAS

SCL,TCL5,bHLHa17,tal-1

FUSION GENES

Show Gene Fusions

DNA/RNA

DNA diagram

Description

8 exons; 16 kb; SIL (a different gene) sits 90 kb further in 5

Transcription

(complex) alternate splicing of: 1A with 2A, or 3 vs 1B, 2B,3 ...or directly 4, 5, 6

Proteins

Description

331 amino acids for the major form of 48 KDa; a truncated form of 26 KDa only in some T-ALL; domains: prolin rich in N-trem; poly Gly; basic Helix-Loop-Helix from the exon 6.

Expression

in hematopoietic stem cells, erythroid and megakaryocytic lineages of the adult and in the embryonic brain; indispensable for the genesis of the hematopoietic system.

Function

transcription factor; exhibits sequence-specific DNA binding activity when in dimers with another bHLH protein such as E2A (DNA specific sequences are: CANNTG, especially: CAGATG); direct interactions of the bHLH with the LIM domain of RBTN2 or RBTN1.

Homology

TAL2 in 9q32; LYL1 in 19p13; more distantly: MYC and other members of the MYC family of Helix-Loop-Helix transcription factors.

Implicated in

Entity name

t(1;7)(p32;q34) or t(1;14)(p32;q11)/T-ALL --> TAL1 - TRB or TAL1 -TRD

Disease

T-cell ALL

Prognosis

is not too poor, compared to other T-ALL

Entity name

T-ALL with normal karyotype, but with submicroscopic deletions of part of TAL1 in the 5 region --> SIL - TAL1

Disease

found in 10 to 30 % of T-ALL with a normal karyotype

Hybrid gene

deletions which place SIL (SCL interrupting sequence) in close 5 of TAL1; hybrid gene with exon 1 from SIL.

Fusion protein

TAL1 is under the promoter sequences controle of SIL, a gene active during T cell development.

Entity name

t(1;3)(p32;p21)/T-ALL --> TAL1 - TCTA

Disease

T-cell ALL

Breakpoints

Note

mainly in 5 in a 1 kb region; but also dispersed in rare cases

Bibliography

Pubmed ID	Last Year	Title	Authors
8471769	1993	Clinical features and outcome of T-cell acute lymphoblastic leukemia in childhood with respect to alterations at the TAL1 locus: a Pediatric Oncology Group study.	Bash RO et al
8760303	1996	The TAL1/Scl basic helix-loop-helix protein blocks myogenic differentiation and E-box dependent transactivation.	Hofmann TJ et al
9020185	1997	Transcriptional activity of TAL1 in T cell acute lymphoblastic leukemia (T-ALL) requires RBTN1 or -2 and induces TALLA1, a highly specific tumor marker of T-ALL.	Ono Y et al
7568177	1995	Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1.	Osada H et al
8689686	1996	The T cell leukemia oncoprotein SCL/tal-1 is essential for development of all hematopoietic lineages.	Porcher C et al
7957052	1994	Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia.	Wadman I et al

Other Information

Locus ID:

NCBI: 6886
MIM: 187040
HGNC: 11556
Ensembl: ENSG00000162367

Variants:

dbSNP: 6886
ClinVar: 6886
TCGA: ENSG00000162367
COSMIC: TAL1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000162367	ENST00000294339	P17542
ENSG00000162367	ENST00000371884	P17542

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
25394790	2014	Oncogene regulation. An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element.	212
21571218	2011	Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators.	116
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
22897851	2012	Core transcriptional regulatory circuit controlled by the TAL1 complex in human T cell acute lymphoblastic leukemia.	80
21179004	2011	Differential genomic targeting of the transcription factor TAL1 in alternate haematopoietic lineages.	60
19497860	2009	LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis.	57
12239153	2002	The SCL complex regulates c-kit expression in hematopoietic cells through functional interaction with Sp1.	56
27052461	2016	Large-scale production of megakaryocytes from human pluripotent stem cells by chemically defined forward programming.	48
23857984	2013	The TAL1 complex targets the FBXW7 tumor suppressor by activating miR-223 in human T cell acute lymphoblastic leukemia.	42
24395799	2014	Analysis of chromatin-state plasticity identifies cell-type-specific regulators of H3K27me3 patterns.	39

Citation

Marie-Claude Labastie ; Jean-Loup Huret

TAL1 (T-cell acute leukemia 1)

Atlas Genet Cytogenet Oncol Haematol. 1998-03-01

Online version: http://atlasgeneticsoncology.org/gene/15/tal1

Historical Card

1997-08-01 TAL1 (T-cell acute leukemia 1) by Jean-Loup Huret,Marie-Claude Labastie Affiliation

Institut dEmbryologie Cellulaire et Moléculaire, CNRS FRE 216O, 94736, Nogent-sur-Marne Cedex, France