dic(1;15)(p11;p11)

Identity

	dic(1;15)(p11;p11) G- banding - Courtesy Catherine Roche-Lestienne, Olivier Theisen, Jean-Luc Lai.

Clinics and Pathology

Disease	Myeloid malignancies
Phenotype / cell stem origin	Myloproliferative diseases (MPD) in 3 of 10 available cases (polycytemia vera (PV) in all 3 cases), myelodysplastic syndromes (MDS) in 6 cases (mainly refractory anaemia (RA): 5 cases; RARS in one case), acute myeloid leukaemia (AML) of M7 type in one case.
Epidemiology	At least 10 cases; balanced sex ratio (5M/5F); median age was 47 yrs (range 15-81)
	Kaplan-Meier on 10 cases of dic(1;15) from the literature; survivals (in months) were: 4, 14, 23+, 24+, 27, 40+, 93+, 96, 235.
Prognosis	About 60% of cases were still alive 2 to 8 yrs after diagnosis (see figure1), but with a too short follow up of a too small cohort, no real conclusions can be drawn. It is likely that the prognosis depend more on the haematological diagnosis (AML versus MDS, vs MPD).

Cytogenetics

Cytogenetics Morphological

presents as-15, + dic(1;15) in most, if not all, cases. It therefore results in trisomy 1q.; sole anomaly in about half cases, accompanied with del(5q) twice, +8 once, del(20q) once.

Genes involved and Proteins

Note	Genes involved are unknown; the translocation breakpoints are likely to be in heterochromatic regions

External links

Other database	dic(1;15)(p11;p11)	Mitelman database (CGAP - NCBI)

To be noted

	Additional cases are needed to delineate the epidemiology of this rare entity: you are welcome to submit a paper to our new Case Report section.
Case Report	Dic(1;15)(p11;p11) as a non-random abnormality in atypical MPD
Case Report	Dic(1;15)(p11;p11) as a non-random abnormality in Polycytemia Vera
Case Report	Dic(1;15)(p11;p11) as a non-random abnormality in Myelodysplasic syndrome

Bibliography

Cytogenetic studies in polycythemia vera.

Wurster-Hill D, Whang-Peng J, McIntyre OR, Hsu LY, Hirschhorn K, Modan B, Pisciotta AV, Pierre R, Balcerzak SP, Murphy S, Weinfeld A

Seminars in hematology. 1976 ; 13 (1) : 13-32.

PMID 1251221

An identical translocation between chromosome 1 and 15 in two patients with myelodysplastic syndromes.

Mecucci C, Tricot G, Boogaerts M, Van den Berghe H

British journal of haematology. 1986 ; 62 (3) : 439-445.

PMID 3954964

Trisomy 1q in polycythemia vera and its relation to disease transition.

Swolin B, Weinfeld A, Westin J

American journal of hematology. 1986 ; 22 (2) : 155-167.

PMID 3706291

A dysmorphic child with myelodysplasia characterized by a duplication of 1q and multiple duplications of 3q.

Mascarello JT, Osborn C, Kadota RP

Cancer genetics and cytogenetics. 1989 ; 38 (1) : 9-12.

PMID 2713819

Cytogenetic analysis of 54 cases of myelodysplastic syndrome.

Jotterand-Bellomo M, Parlier V, Schmidt PM, Beris P

Cancer genetics and cytogenetics. 1990 ; 46 (2) : 157-172.

PMID 2340487

Dicentric (1;15) in myeloid disorders.

Michaux L, Dierlamm J, Mecucci C, Meeus P, Ameye G, Libouton JM, Verhoef G, Ferrant A, Louwagie A, Verellen-Dumoulin C, Van Den Berghe H

Cancer genetics and cytogenetics. 1996 ; 88 (1) : 86-89.

PMID 8630988

Cytogenetic profile of childhood and adult megakaryoblastic leukemia (M7): a study of the Groupe Franˆßais de Cytogˆ©nˆ©tique Hˆ©matologique (GFCH).

Dastugue N, Lafage-Pochitaloff M, Pagˆ®s MP, Radford I, Bastard C, Talmant P, Mozziconacci MJ, Lˆ©onard C, Bilhou-Nabˆ©ra C, Cabrol C, Capodano AM, Cornillet-Lefebvre P, Lessard M, Mugneret F, Pˆ©rot C, Taviaux S, Fenneteaux O, Duchayne E, Groupe Franˆßais d'Hematologie Cellulaire, Berger R

Blood. 2002 ; 100 (2) : 618-626.

PMID 12091356

Contributor(s)

Written	08-2007	Jean-Loup Huret
		Genetics, Dept Medical Information, University of Poitiers; CHU Poitiers Hospital, F-86021 Poitiers, France

Citation

This paper should be referenced as such :

Huret JL . dic(1;15)(p11;p11). Atlas Genet Cytogenet Oncol Haematol. August 2007 . URL : http://AtlasGeneticsOncology.org/Genes/dic0115p11p11ID1159.html

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indexed on : Sat Dec 6 18:01:49 2008

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