Atlas of Genetics and Cytogenetics in Oncology and Haematology
i(5)(p10) in acute myeloid leukemia
| Identity |
| Note | The isochromosome of the short arm of chromosome 5 - i(5)(p10) - has only been described in a few cases of myeloid leukemia. So far it has not been described as the sole abnormality. In four cases the i(5)(p10) was accompanied by trisomy 8, in three cases the i(5)(p10) occurred in addition to two normal chromosomes 5. An i(5)(p10) was also described in cases with a complex aberrant karyotype |
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| i(5)(p10) G-banding - Claudia Schoch | |
| Clinics and Pathology |
| Phenotype / cell stem origin | Classified as AML, predominantly AML M5a |
| Etiology | Unclear |
| Epidemiology | Mean age 40-50 yrs |
| Clinics | Blood data WBC 8-40 x 109l, platelet counts 15-114 x 109l |
| Cytology | Typical cytomorphological features of AML M5a with more than 80% of bone marrow cells being monoblasts showing strong cytochemical reaction with nonspecific esterase. Expression of CD33 and CD65. |
| Treatment | According to AML protocols. |
| Prognosis | Unclear due to low number of cases, seems to be poor. |
| Cytogenetics |
| Cytogenetics Morphological | Isochromosome of the short arm of chromosome 5 |
| Additional anomalies | trisomy 8, gain of chromosome 5 |
| Genes involved and Proteins |
| Note | Gene dosage effect of genes located on the short arm of chromosome 5? |
| External links |
| Other database | i(5)(p10) in acute myeloid leukemia | Mitelman database (CGAP - NCBI) |
| To be noted |
| Additional cases are needed to delineate the epidemiology of this rare entity: you are welcome to submit a paper to our new Case Report section. |
| Bibliography |
| Chromosomal breakpoints and changes in DNA copy number in refractory acute myeloid leukemia. |
| El-Rifai W, Elonen E, Larramendy M, Ruutu T, Knuutila S |
| Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 1997 ; 11 (7) : 958-963. |
| PMID 9204975 |
| Cytogenetic analysis of de novo acute myeloid leukemia with trilineage myelodysplasia in comparison with myelodysplastic syndrome evolving to acute myeloid leukemia. |
| Tamura S, Takemoto Y, Hashimoto-Tamaoki T, Mimura K, Sugahara Y, Senoh J, Furuyama JI, Kakishita E |
| International journal of oncology. 1998 ; 12 (6) : 1259-1262. |
| PMID 9592183 |
| Lack of BCR/ABL reciprocal fusion in variant Philadelphia chromosome translocations: a use of double fusion signal FISH and spectral karyotyping. |
| Markovic VD, Bouman D, Bayani J, Al-Maghrabi J, Kamel-Reid S, Squire JA |
| Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 2000 ; 14 (6) : 1157-1160. |
| PMID 10865986 |
| Gain of an isochromosome 5p: a new recurrent chromosome abnormality in acute monoblastic leukemia. |
| Schoch C, Bursch S, Kern W, Schnittger S, Hiddemann W, Haferlach T |
| Cancer genetics and cytogenetics. 2001 ; 127 (1) : 85-88. |
| PMID 11408074 |
| Contributor(s) |
| Written | 02-2005 | Claudia Schoch |
| Citation |
| This paper should be referenced as such : |
| Schoch C . i(5)(p10) in acute myeloid leukemia. Atlas Genet Cytogenet Oncol Haematol. February 2005 . URL : http://AtlasGeneticsOncology.org/Genes/i5pID1376.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Sat Dec 6 18:01:53 2008 |
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