| Clinics and Pathology |
| Disease | acute lymphoblastic leukemia (ALL) |
| Phenotype / cell stem origin | B precursor ALL |
| Epidemiology | a rare type of leukaemia; near-haploid patients tend to be children or teenagers; slight excess of females |
| Prognosis | generally short complete remission duration and poor prognosis, although long survivors have been reported |
| Cytogenetics |
| Cytogenetics Morphological | near haploidy is usually defined as <30 chromosomes; typically the abnormal clone has 23-28 chromosomes; the pattern of chromosome loss in near-haploidy is not random as there is preferential retention of two copies of chromosomes 6, 8, 10, 14, 18, 21, and the sex chromosomes; in addition to the haploid clone it is common to see a normal diploid clone and a cell line with double the near-haploid number of chromosomes, resulting in hyperdiploidy; occasionally the near-haploid clone is hard to detect resulting in apparent hyperdiploidy; the hyperdiploid cells however tend to have 2 or 4 copies of chromosomes and can thus be distinguished from typical >50 hyperdiploid ALL; the distinction is important as near-haploidy defines a rare type of childhood ALL associated with short median complete remission duration and poor prognosis |
| Additional anomalies | occasional structural chromosome abnormality |
| Bibliography |
| Acute lymphoblastic leukemia with a hypodiploid karyotype with less than 40 chromosomes: the basis for division into two subgroups. |
| Callen DF, Raphael K, Michael PM, Garson OM |
| Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 1989 ; 3 (10) : 749-752. |
| PMID 2779290 |
| Clinical presentation, karyotypic characterization, and treatment outcome of childhood acute lymphoblastic leukemia with a near-haploid or hypodiploid less than 45 line. |
| Pui CH, Carroll AJ, Raimondi SC, Land VJ, Crist WM, Shuster JJ, Williams DL, Pullen DJ, Borowitz MJ, Behm FG |
| Blood. 1990 ; 75 (5) : 1170-1177. |
| PMID 2306521 |
| Near haploid acute lymphoblastic leukemia: seven new cases and a review of the literature. |
| Gibbons B, MacCallum P, Watts E, Rohatiner AZ, Webb D, Katz FE, Secker-Walker LM, Temperley IJ, Harrison CJ, Campbell RH |
| Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 1991 ; 5 (9) : 738-743. |
| PMID 1943226 |
| Formation of a hyperdiploid karyotype in childhood acute lymphoblastic leukemia. |
| Onodera N, McCabe NR, Rubin CM |
| Blood. 1992 ; 80 (1) : 203-208. |
| PMID 1351763 |
| Hyperdiploidy arising from near-haploidy in childhood acute lymphoblastic leukemia. |
| Onodera N, McCabe NR, Nachman JB, Johnson FL, Le Beau MM, Rowley JD, Rubin CM |
| Genes, chromosomes & cancer. 1992 ; 4 (4) : 331-336. |
| PMID 1377941 |
| Near-haploid common acute lymphoblastic leukaemia of childhood with a second hyperdiploid line: a DNA ploidy and fluorescence in-situ hybridization study. |
| Ma SK, Chan GC, Wan TS, Lam CK, Ha SY, Lau YL, Chan LC |
| British journal of haematology. 1998 ; 103 (3) : 750-755. |
| PMID 9858226 |
| Contributor(s) |
| Written | 06-1999 | Barbara Gibbons |
| Citation |
| This paper should be referenced as such : |
| Gibbons B . Near haploid acute lymphoblastic leukaemia. Atlas Genet Cytogenet Oncol Haematol. June 1999 . URL : http://AtlasGeneticsOncology.org/Genes/nearhaploidID1145.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Sat Dec 6 18:02:00 2008 |
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