| Clinics and Pathology |
| Disease | Acute myeloid leukaemia (AML); non-Hodgkin lymphoma (NHL) |
| Note | The disease is likely to be heterogeneous, with different phenotypes (AML and NHL) for a given breakpoint (1p31 and 8q22), and possibly similar or different breakpoints in different AML cases. |
| Epidemiology | 3 cases of AML: two of which were M2 cases (ages and sex were: 84 years/F; 40 years/ M; ?/?); the NHL case was 71 year-old male patient with a small cleaved cell follicular lymphoma |
| Cytogenetics |
| Additional anomalies | Complex karyotypes in all the available cases; a del(5q) and a t(8;21)(q22;q22) in a M2-AML |
| Genes involved and Proteins |
| Note | Genes involved are unknown. |
| To be noted |
| Additional cases are needed to delineate the epidemiology of this rare entity: you are welcome to submit a paper to our new Case Report section. |
| Bibliography |
| Nonrandom chromosome abnormalities in lymphoma. |
| Bloomfield CD, Arthur DC, Frizzera G, Levine EG, Peterson BA, Gajl-Peczalska KJ |
| Cancer research. 1983 ; 43 (6) : 2975-2984. |
| PMID 6850608 |
| Acute megakaryocytic leukemia. |
| Moertel CL, Miser JS |
| Mayo Clinic proceedings. Mayo Clinic. 1990 ; 65 (3) : 437-438. |
| PMID 2353967 |
| Complex chromosome translocations of standard t(8;21) and t(15;17) arise from a two-step mechanism as evidenced by fluorescence in situ hybridization analysis. |
| Calabrese G, Min T, Stuppia L, Powles R, Swansbury JG, Morizio E, Peila R, Donti E, Fioritoni G, Palka G |
| Cancer genetics and cytogenetics. 1996 ; 91 (1) : 40-45. |
| PMID 8908165 |
| Acute leukemia cytogenetics: an evaluation of combining G-band karyotyping with multi-color spectral karyotyping. |
| Kerndrup GB, Kjeldsen E |
| Cancer genetics and cytogenetics. 2001 ; 124 (1) : 7-11. |
| PMID 11165315 |
| Identification of cytogenetic subclasses and recurring chromosomal aberrations in AML and MDS with complex karyotypes using M-FISH. |
| Van Limbergen H, Poppe B, Michaux L, Herens C, Brown J, Noens L, Berneman Z, De Bock R, De Paepe A, Speleman F |
| Genes, chromosomes & cancer. 2002 ; 33 (1) : 60-72. |
| PMID 11746988 |
| Contributor(s) |
| Written | 02-2008 | Jean-Loup Huret |
| Jean Loup HURET, Genetics, Dept Medical Information, University of Poitiers; CHU Poitiers Hospital, F-86021 Poitiers, France |
| Citation |
| This paper should be referenced as such : |
| Huret JL . t(1;8)(p22-p32;q22-q23). Atlas Genet Cytogenet Oncol Haematol. February 2008 . URL : http://AtlasGeneticsOncology.org/Genes/t0108p31q22ID1207.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Sat Dec 6 18:02:05 2008 |
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