| Clinics and Pathology |
| Disease | only 3 cases of myelodysplastic syndrome (MDS) and 1 case of non Hodgkin lymphoma (NHL). The 3 MDS cases were: 2 refractory anemia with excess of blasts (RAEB), evolving towards M2 acute non lymphocytic leukemia (ANLL), and 1 refractory anemia with ringed sideroblasts (RARS) evolving towards M6-ANLL; the NHL case was a VIH-associated large cell NHL. |
| Epidemiology | the MDS cases were aged 59-74 yrs, the NHL patient was 29 yr old; sex ratio: 4M/0F. |
| Prognosis | survival in MDS: 13 mths, 15 mths+, 54 mths+; death of an unrelated cause in the NHL. |
| Cytogenetics |
| Cytogenetics Morphological | presents as a der(16) t(1;16) in the 3 MDS |
| Additional anomalies | sole anomaly in 1 MDS, accompanied with +8 in the 2 other MDS cases; the NHL case exhibited a t(8;14)(q24;q11) and a complex caryotype; i.e. probable primary anomaly in MDS, secondary anomaly in the NHL case |
| Genes involved and Proteins |
| Note | genes involved are unknown. |
| External links |
| Other database | t(1;16)(q11;q11) | Mitelman database (CGAP - NCBI) | |
| Other database | t(1;16)(q11;q11) | CancerChromosomes (NCBI) |
| To be noted |
| Additional cases are needed to delineate the epidemiology of this rare entity: you are welcome to submit a paper to our new Case Report section. |
| Bibliography |
| Centromeric instability of chromosome 1 resulting in multibranched chromosomes, telomeric fusions, and jumping translocations of 1q in a human immunodeficiency virus-related non-Hodgkin's lymphoma. |
| Sawyer JR, Swanson CM, Koller MA, North PE, Ross SW |
| Cancer. 1995 ; 76 (7) : 1238-1244. |
| PMID 8630904 |
| Der(16)t(1;16)(q11;q11) in myelodysplastic syndromes: a new non-random abnormality characterized by cytogenic and fluorescence in situ hybridization studies. |
| Mugneret F, Dastugue N, Favre B, Sidaner I, Salles B, Huguet-Rigal F, Solary E |
| British journal of haematology. 1995 ; 90 (1) : 119-124. |
| PMID 7786773 |
| Contributor(s) |
| Written | 05-2002 | Jean-Loup Huret |
| Citation |
| This paper should be referenced as such : |
| Huret JL . t(1;16)(q11;q11). Atlas Genet Cytogenet Oncol Haematol. May 2002 . URL : http://AtlasGeneticsOncology.org/Genes/t0116q11q11ID1247.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Sat Dec 6 18:02:10 2008 |
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