| Clinics and Pathology |
| Disease | acute non lymphocytic leukemia (ANLL) and acute lymphocycic leukemia (ALL) |
| Phenotype / cell stem origin | M2 and M6ANLL, L2-ALL |
| Etiology | 1 case was a therapy related ANLL, and the 2 other cases were found in Down syndrome (DS) patients |
| Epidemiology | poorly known: only 3 cases to date; 3 female patients aged 1-13 yrs |
| Prognosis | yet unknown : cases dead at 1 mth and alive at 2 mths+ (2 DS cases), alive at 12 mths+ (therapy related case) |
| Cytogenetics |
| Cytogenetics Morphological | found as -18, +der(18)t(1;18)(q25;q23) in 2 of the 3 cases; unbalanced form, with 2 normal chromosomes 1, a der(18), and a normal chromosome 18: --> partial trisomy for 1q25-1qter and monosomy for 18q23-qter; reminiscent of the t(1;19)(q23;p13) unbalanced form |
| External links |
| Other database | t(1;18)(q25;q23) | Mitelman database (CGAP - NCBI) | |
| Other database | t(1;18)(q25;q23) | CancerChromosomes (NCBI) |
| To be noted |
| Additional cases are needed to delineate the epidemiology of this rare entity: you are welcome to submit a paper to our new Case Report section. |
| Bibliography |
| Cytogenetic findings in leukemic cells of 56 patients with constitutional chromosome abnormalities. A cooperative study. Groupe Franˆßais de Cytogˆ©nˆ©tique Hˆ©matologique. |
| Cancer genetics and cytogenetics. 1988 ; 35 (2) : 243-252. |
| PMID 2972356 |
| Two karyotypically independent leukemic clones with the t(8;21) and 11q23 translocation in acute myeloblastic leukemia at relapse. |
| Hayashi Y, Raimondi SC, Behm FG, Santana VM, Kalwinsky DK, Pui CH, Mirro J Jr, Williams DL |
| Blood. 1989 ; 73 (6) : 1650-1655. |
| PMID 2713498 |
| A second known case of Down syndrome with t(1;18)(q25;q23) in leukemic cells. |
| Brozek I, Babi‰Ñska M, Limon J, Zaborowska-So‰Çtys M, P‰Çoszy‰Ñska A, Balcerska A |
| Cancer genetics and cytogenetics. 1999 ; 110 (2) : 136-137. |
| PMID 10214363 |
| Contributor(s) |
| Written | 09-1999 | Jean-Loup Huret |
| Citation |
| This paper should be referenced as such : |
| Huret JL . t(1;18)(q25;q23). Atlas Genet Cytogenet Oncol Haematol. Septem
ber 1999 . URL : http://AtlasGeneticsOncology.org/Genes/t0118ID1162.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Sat Dec 6 18:02:11 2008 |
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