| Clinics and Pathology |
| Disease | Non Hodgkin lymphoma (NHL) and myelodysplastic syndrome (chronic myelomonocytic leukemia (CMML) |
| Epidemiology | Only 2 cases to date (male patients): 1 NHL aged 30 yrs and 1 CMML aged 78 yrs |
| Prognosis | The CMML case died 2 yrs 9 mths after diagnosis |
| Cytogenetics |
| Additional anomalies | del(11q) in the NHL case and +21 in the CMML case |
| Genes involved and Proteins |
| Note | ETV6 was found involved in the NHL case |
| External links |
| Other database | t(2;12)(q31;p13) | Mitelman database (CGAP - NCBI) | |
| Other database | t(2;12)(q31;p13) | CancerChromosomes (NCBI) |
| To be noted |
| Additional cases are needed to delineate the epidemiology of this rare entity: you are welcome to submit a paper to our new Case Report section. | |
| Case Report | Reciprocal translocation t(2;12)(q31;p13) in a case of CMML |
| Bibliography |
| Heterogeneity in the breakpoints in balanced rearrangements involving band 12p13 in hematologic malignancies identified by fluorescence in situ hybridization: TEL (ETV6 ) is involved in only one half. |
| Sato Y, Bohlander SK, Kobayashi H, Reshmi S, Suto Y, Davis EM, Espinosa R, Hoopes R, Montgomery KT, Kucherlapati RS, Le Beau MM, Rowley JD |
| Blood. 1997 ; 90 (12) : 4886-4893. |
| PMID 9389705 |
| Contributor(s) |
| Written | 11-2006 | Jean Loup Huret |
| Citation |
| This paper should be referenced as such : |
| Huret JL . t(2;12)(q31;p13). Atlas Genet Cytogenet Oncol Haematol. November 2006 . URL : http://AtlasGeneticsOncology.org/Genes/t0212q31p13ID1459.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Sat Dec 6 18:02:18 2008 |
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