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t(2;14)(p13;q32)

Clinics and Pathology

Disease Found so far in 6 cases of chronic lymphocytic leukemia (CLL), 1 diffuse, mixed small/large cell non Hogkin lymphoma (NHL), and 3 cases of acute lymphocytic leukemia (ALL): one T-ALL and two (CD10+) B-ALL
Epidemiology sex ratio: 5 male and 5 female patients; CLL cases were aged 10, 15, 58, 59, and 62 yrs; ALL cases were 2, 4, and 5 yr old children
Prognosis 5 CLL cases were dead after 27-49 mths survival; the 3 ALL cases were alive at 29+-34+ mths of follow up

Cytogenetics

Cytogenetics Morphological sole anomaly in 2 of 8 documented cases; often found in complex karyotypes; no recurrent accompanying anomaly so far.

Genes involved and Proteins

Gene Name BCL11A
Location 2p13-15
Protein 6 Kruppel C2H2 zinc fingers, a prolin rich domain, and an acidic domain
Gene Name IgH
Location 14q32

External links

Other databaset(2;14)(p13;q32) Mitelman database (CGAP - NCBI)
Other databaset(2;14)(p13;q32) CancerChromosomes (NCBI)

Bibliography

A 14;19 translocation in B-cell chronic lymphocytic leukemia: a new recurring chromosome aberration.
Ueshima Y, Bird ML, Vardiman JW, Rowley JD
International journal of cancer. Journal international du cancer. 1985 ; 36 (3) : 287-290.
PMID 3875568
 
Nonrandom rearrangement of chromosome 14 at band q32.33 in human lymphoid malignancies with mature B-cell phenotype.
Nishida K, Taniwaki M, Misawa S, Abe T
Cancer research. 1989 ; 49 (5) : 1275-1281.
PMID 2492904
 
Immunophenotype-karyotype associations in human acute lymphoblastic leukemia.
Uckun FM, Gajl-Peczalska KJ, Provisor AJ, Heerema NA
Blood. 1989 ; 73 (1) : 271-280.
PMID 2910365
 
Childhood chronic lymphocytic leukemia with (2;14) translocation.
Yoffe G, Howard-Peebles PN, Smith RG, Tucker PW, Buchanan GR
The Journal of pediatrics. 1990 ; 116 (1) : 114-117.
PMID 2295951
 
t(2;14)(p13;q32): a recurring abnormality in lymphocytic leukemia. A Pediatric Oncology Group study.
Watson MS, Land VJ, Carroll AJ, Pullen J, Borowitz MJ, Link MP, Amylon M, Behm FG
Cancer genetics and cytogenetics. 1992 ; 58 (2) : 121-124.
PMID 1551073
 
In B-cell chronic lymphocytic leukaemia chromosome 17 abnormalities and not trisomy 12 are the single most important cytogenetic abnormalities for the prognosis: a cytogenetic and immunophenotypic study of 480 unselected newly diagnosed patients.
Geisler CH, Philip P, Christensen BE, Hou-Jensen K, Pedersen NT, Jensen OM, Thorling K, Andersen E, Birgens HS, Drivsholm A, Ellegaard J, Larsen JK, Plesner T, Brown P, Andersen PK, Hansen MM
Leukemia research. 1997 ; 21 (11-12) : 1011-1023.
PMID 9444933
 
A plasma cell leukemia patient showing bialleic 14q translocations: t(2;14) and t(11;14).
Sonoki T, Matsuzaki H, Satterwhite E, Nakazawa N, Hata H, Tucker PW, Taniwaki M, Kuribayashi N, Harada N, Matsuno F, Mitsuya H
Acta haematologica. 1999 ; 101 (4) : 197-201.
PMID 10436301
 
The BCL11 gene family: involvement of BCL11A in lymphoid malignancies.
Satterwhite E, Sonoki T, Willis TG, Harder L, Nowak R, Arriola EL, Liu H, Price HP, Gesk S, Steinemann D, Schlegelberger B, Oscier DG, Siebert R, Tucker PW, Dyer MJ
Blood. 2001 ; 98 (12) : 3413-3420.
PMID 11719382
 

Contributor(s)

Written06-2002Jean Loup Huret

Citation

This paper should be referenced as such :
Huret JL . t(2;14)(p13;q32). Atlas Genet Cytogenet Oncol Haematol. June 2002 .
URL : http://AtlasGeneticsOncology.org/Genes/t0214p13q32ID1231.html

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indexed on : Sat Dec 6 18:02:18 2008


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