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Chromosome 21

Chromosome 21 : G-banding, diagram and R-banding - Claude Léonard, Jean-Loup Huret

Leukaemia     

t(1;21)(p36;q22)
t(1;21)(p32;q22)
t(1;21)(p35;q22)
t(1;21)(q21;q22)
t(2;21)(p11;q22)
t(3;21)(q26;q22)
t(3;21)(q26;q22) in treatment related leukemia
t(4;21)(q31;q22)
t(4;21)(q31;q22)
t(5;21)(q13;q22)
t(6;21)(p22;q22)
t(7;21)(p22;q22)
t(8;21)(q22;q22)
t(8;21)(q22;q22) in treatment related leukemia
t(8;21)(q24;q22)
t(9;21)(p22;q22)
t(9;21)(q34;q22)
t(X;21)(q26;q22) (AML; ELF4 and ERG; rare)
t(X;21)(p22;q22)
t(12;21)(p12;q22)
t(12;21)(q12;q22)
t(12;21)(q24;q22)
t(14 ;21)(q11;q22)
t(14;21)(q22;q22)
t(15;21)(q22;q22)
t(16;21)(p11;q22)
t(16;21)(q24;q22)
t(17;21)(q11.2;q22)
t(18;21)(q21;q22)
t(19;21)(q13.4;q22)
t(20;21)(q11;q22)
t(20;21)(q13;q22)
21q22 rearrangements in treatment related leukemia
dup(21q) amplified (RUNX1)
-21 or monosomy 21 (solely)
+21 or trisomy 21

Solid Tumors     

t(16;21)(p11;q22)
t(21;22)(q12;q12)
t(17;22)(q12;q12)

Cancer prone diseases     

Familial platelet disorder with predisposition to acute myelogenous leukemia (FPD/AML)

All Genes by Location (Kb)
Chromosome 21 by location

Losses / Amplicons     

BONE/SOFT TISSUE

External links     

  • Chromosome 21 - HUGO Chromosomes
  • Chromosome 21 - GoldenPath - Santa Cruz
  • Chromosome 21 - Ensembl Project
  • Chromosome 21 - Map View - NCBI
  • Chromosome 21 - GDB (Genome Data Base)
  • Chromosome 21 - OMIM Gene map
  • Chromosome 21 - Genomic Variants
  • Chromosome 21 - HAPMAP Project
  • Chromosome 21 - Genome Channel - ORNL
  • Chromosome 21 - LaunchPad HGMIS
  • Chromosome 21 - Human Protein Atlas
  • Chromosome 21 - SpliceNest
  • Human BAC Resource (NCBI)
  • FISH-mapped BACs (CCAP)
  • Genetic Maps (CHLC)
  • YACs mapped by FISH (Bari)
  • PCP (Partial Chromosome Paints) (Bari)
  • Positional Cloning Project (Berlin Dahlem)
  • Mouse homology - OMIM - NCBI
  • Cancer GeneWeb
  • GeneCards (Weizmann)
  • Human Proteomics Initiative (Expasy)

    • Genes

    Annotated genes
    Ordered by Name Ordered by Location
     Kb pter-qter
    CSTB 44018.259 21q22.3
    ERG 38675.671 21q22.3
    ETS2 39099.719 21q22.3|21q22.2
    MIRN125B2 16884.428 21
    OLIG2 33320.109 21q22.11
    PTTG1IP 45093.941 21q22.3
    RUNX1 35081.968 21q22.3
    S100B 46842.959 21q22.3
    TFF1 42655.460 21q22.3
    TFF2 42639.538 21q22.3
    TFF3 42605.232 21q22.3
    TIAM1 31412.607 21q22.1|21q22.11
    TMPRSS3 42665.068 21q22.3
    Other genes
    possibly implicated
    in cancer
    Ordered by Name Ordered by Location
     Kb pter-qter
    ADAMTS1 27130.477 21q21.3
    ADAMTS5 27212.103 21q21.3
    ADARB1 45318.943 21q22.3
    AIRE 44530.191 21q22.3
    APP 26174.732 21q21.2
    B3GALT5 39951.124 21q22.3
    BACE2 41461.598 21q22.3
    BACH1 29599.431 21q22.1
    BAGE 10079.667 13
    BAGE2 10042.713 21p
    BAGE3 10042.713 21p11.2
    BAGE4 10042.713 21p11.1
    BAGE5 10042.713 13cen
    BIC 25856.375 21q21.3
    BTG3 17887.842 21q21.1
    C21orf33 44377.922 21q22.3
    CBR3 36429.133 21q22.2
    CBS 43346.370 21q22.3
    CHAF1B 36679.559 21q22.2
    CLDN8 30508.201 21q22.11
    COL18A1 45699.852 21q22.3
    COL6A1 46226.091 21q22.3
    CXADR 17807.201 21q21.1
    CYYR1 26760.399 21q21.2
    DNMT3L 44490.651 21q22.3
    DYRK1A 37714.472 21q22.13
    GABPA 26029.200 21q21-q22.1|21q21.3
    HMGN1 39636.111 21q22.3|21q22.2
    HSPA13 14665.308 21q11.1
    HUNK 32167.499 21q22.1
    ICOSLG 44471.150 21q22.3
    IFNAR1 33619.084 21q22.1|21q22.11
    IFNAR2 33524.101 21q22.1|21q22.11
    IFNGR2 33697.072 21q22.11
    ITGB2 45130.297 21q22.3
    ITSN1 33936.654 21q22.1-q22.2
    KCNE1 34740.858 21q22.1-q22.2
    KCNJ6 37918.657 21q22.1
    MCM3AP 46479.476 21q22.3
    MIRN155 25868.163 21q21.3
    NCAM2 21292.504 21q21.1
    NRIP1 15255.427 21q11.2
    OLIG1 33364.443 21q22.11
    PCBP3 46094.303 21q22.3
    PCNT 46568.464 21q22.3
    PFKL 44544.358 21q22.3
    PIGP 37359.534 21q22.2
    PKNOX1 43267.712 21q22.3
    PRMT2 46879.955 21q22.3
    PRSS7 18563.561 21q21|21q21.1
    RIPK4 42032.598 21q22.3
    RRP1B 43903.860 21q22.3
    SAMSN1 14779.420 21q11
    SIM2 36993.861 21q22.2|21q22.13
    SLC19A1 45759.057 21q22.3
    SLC5A3 34367.740 21q22
    SNF1LK 43658.827 21q22.3
    SOD1 31953.806 21q22.11
    SON 33837.220 21q22.1-q22.2|21q22.11
    SYNJ1 32922.944 21q22.2
    TMPRSS2 41758.351 21q22.3
    U2AF1 43386.135 21q22.3
    UBE2G2 45013.383 21q22.3
    USP25 16024.367 21q11.2

    GeneCards   GDB - List of genes

    This page should be referenced as such :
    Dessen P, Knuutila S, Huret JL Chromosome 21. Atlas Genet Cytogenet Oncol Haematol. 2002.
    URL : http://AtlasGeneticsOncology.org/Indexbychrom/idxa_21.html
    © Atlas of Genetics and Cytogenetics in Oncology and Haematology
    indexed on : Sat Nov 8 19:45:49 2008
    Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case reports   Journals   Portal   Teaching   

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