Atlas of Genetics and Cytogenetics in Oncology and Haematology

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Chromosome 4

Chromosome 4 : G-banding, diagram and R-banding - Claude Léonard, Jean-Loup Huret

Leukaemia     

t(2;4)(p22;q12)
t(2;4)(p23;q25-q35)
t(3;4)(p21;q34)
t(3;4)(q27;p13)
ins(9;4)(q33;q12q25) (MPD; PDGFRa and CDK5RAP2; rare)
del(4)(q12q12) (MPD; PDGFRa and FIP1L1; not rare)
t(4;10)(q12;p11)
+4 or trisomy 4
t(4;5)(q31;q31)
t(4;11)(q21;q23)
t(4;11)(p12;q23)
t(4;11)(q21;p15)
t(4;11)(q35;q23)
t(4;11)(q35;q23) (AML; ArgBP2 and MLL; rare)
t(4;12)(q11-q21;p13)
t(4;12)(p16;p13)
t(4;12)(q12;p13) PDGFRA/ETV6
t(4;14)(p16;q32)
t(4;16)(q26;p13)
t(4;17)(q12;q21)
t(4;21)(q31;q22)
t(4;21)(q31;q22)
t(4;22)(q12;q11.2)

Solid Tumors     

Cancer prone diseases     

Familial /sporadic gastrointestinal stromal tumors (GISTs)
Piebaldism

All Genes by Location (Kb)
Chromosome 4 by location

Losses / Amplicons     

BONE/SOFT TISSUE

External links     

  • Chromosome 4 - HUGO Chromosomes
  • Chromosome 4 - GoldenPath - Santa Cruz
  • Chromosome 4 - Ensembl Project
  • Chromosome 4 - Map View - NCBI
  • Chromosome 4 - GDB (Genome Data Base)
  • Chromosome 4 - OMIM Gene map
  • Chromosome 4 - Genomic Variants
  • Chromosome 4 - HAPMAP Project
  • Chromosome 4 - Genome Channel - ORNL
  • Chromosome 4 - LaunchPad HGMIS
  • Chromosome 4 - Human Protein Atlas
  • Chromosome 4 - SpliceNest
  • Human BAC Resource (NCBI)
  • FISH-mapped BACs (CCAP)
  • Genetic Maps (CHLC)
  • YACs mapped by FISH (Bari)
  • PCP (Partial Chromosome Paints) (Bari)
  • Positional Cloning Project (Berlin Dahlem)
  • Mouse homology - OMIM - NCBI
  • Cancer GeneWeb
  • GeneCards (Weizmann)
  • Human Proteomics Initiative (Expasy)

    • Genes

    Annotated genes
    Ordered by Name Ordered by Location
     Kb pter-qter
    AFF1 88147.177 4q21.3
    CHIC2 54570.715 4q11
    FGA7 138753.188 4q28
    FGFR3 1764.837 4p16.3
    FRYL 48194.137 4p12
    KIT 55218.852 4q11-q12
    MAD2L1 121200.025 4q27
    MAPK10 87156.656 4q22-q23
    NFKB1 103641.518 4q24
    PTPN13 87734.492 4q21.3
    RAP1GDS1 99401.550 4q23-q25
    RCHY1 76623.371 4q21.1-q21.3
    RHOH 39874.922 4p13
    S100P 6746.467 4p16
    SORBS2 186743.592 4q35.1
    SYNPO2 120029.444 4q26
    Other genes
    possibly implicated
    in cancer
    Ordered by Name Ordered by Location
     Kb pter-qter
    AASDH 56899.214 4q12
    ABCE1 146238.606 4q31
    ABCG2 89230.440 4q22-q23
    ACOX3 8418.909 4p15.3
    ACSL1 185913.743 4q35
    ADAM29 176076.084 4q34
    ADAMTS3 73365.551 4q13.3
    ADH1A 100416.547 4q23
    ADH1B 100446.550 4q23
    ADH1C 100476.672 4q23
    ADH4 100263.856 4q22
    ADH5 100211.153 4q23
    ADH6 100344.902 4q23
    ADH7 100552.441 4q23-q24
    AFAP1 7811.340 4p16
    AFP 74520.797 4q11-q13
    AGA 178588.918 4q34.3
    AGPAT9 84676.677 4q21.23
    AGXT2L1 109882.651 4q25
    ALB 74488.870 4q13.3
    ANK2 113958.688 4q25-q27
    ANKRD17 74159.366 4q21.1-q21.21
    ANP32C 165337.609 4q32.3
    ANXA5 122808.602 4q27
    AREG 75529.717 4q13-q21
    ARFIP1 153920.562 4q31.3
    ARHGAP10 148872.903 4
    ARHGAP24 86615.308 4q22.1
    ATOH1 94969.101 4q22
    BDH2 104218.231 4q24
    BMP3 82171.143 4q21
    BMPR1B 95898.151 4q23-q24
    BTC 75890.472 4q13-q21
    C1QTNF7 14950.710 4p16-p15
    C4orf17 100651.223 4q23
    C4orf21 113730.235 4q25
    C4orf36 88016.382 4q21.3
    CAMK2D 114595.014 4q26
    CASP3 185785.844 4q34
    CASP6 110829.234 4q25
    CCDC110 186603.341 4q35.1
    CCKAR 26092.116 4p15.1-p15.2
    CCNA2 122957.049 4q25-q31
    CCNG2 78297.381 4q21.22
    CCNI 78188.199 4q21.1
    CCRN4L 140156.393 4q28.3
    CD38 15389.029 4p15.32
    CDKL2 76720.728 4q21.1
    CDKN2AIP 184602.783 4q35.1
    CDS1 85723.081 4q21
    CENPC1 68020.584 4q13.2
    CENPE 104246.412 4q24-q25
    CFI 110881.297 4q25
    COL25A1 109964.488 4q25
    COPS4 84175.263 4q21.22
    COQ2 84404.001 4q21.23
    COX7B2 46431.604 4p12
    CPE 166519.547 4
    CRMP1 5873.392 4p16.1
    CTBP1 1195.228 4p16
    CXCL1 74953.973 4q13.3
    CXCL10 77161.295 4q21
    CXCL11 77173.864 4q21.2
    CXCL13 78651.931 4q21
    CXCL2 75181.618 4q13.3
    CXCL3 75121.176 4q21
    CXCL5 75080.223 4q13.3
    CXCL6 74921.137 4q13.3
    CXCL9 77141.647 4q21
    CXXC4 105612.792 4q22-q24
    DC2 109791.190 4q25
    DCK 72078.129 4q13.3-q21.1
    DCLK2 151219.530 4q31.3
    DCTD 184048.238 4q35.1
    DGKQ 942.675 4p16.3
    DKK2 108062.408 4q25
    DMP1 88790.483 4q21
    DNAJB14 101040.701 4q23
    DSPP 88748.705 4q21.3
    EDNRA 148621.357 4q31.23
    EGF 111053.489 4q25
    EIF4E 100018.630 4q21-q25
    ELF2 140198.321 4q28
    ELOVL6 111189.679 4q25
    EMCN 101538.007 4q22.1
    ENOPH1 83570.750 4q21.3
    ENPEP 111616.678 4q25
    ENPP6 185246.854 4q35.1
    EPGN 75393.068 4q13.3
    EPHA5 65872.241 4q13.1
    EREG 75449.724 4q13.3
    EXOC1 56414.573 4q12
    F11 187424.112 4q35
    FABP2 120457.853 4q28-q31
    FAM149A 187307.321 4q35.2
    FAM175A 84601.120 4q21.23
    FAT 187745.931 4q35.2
    FAT4 126457.017 4q28.1
    FBXO8 175394.385 4q34.1
    FBXW7 153461.860 4q31.3
    FGA 155723.730 4q28
    FGB 155703.582 4q28
    FGF2 123967.313 4q26-q27
    FGF5 81406.766 4q21
    FGFBP1 15546.290 4p15.32
    FGFRL1 995.610 4p16
    FGG 155744.736 4q28
    FIP1L1 53938.620 4q11-q12
    FLJ20184 106693.226 4q24
    G3BP2 76786.977 4q21.1
    GAB1 144477.500 4q31.1
    GAK 833.065 4p16
    GC 72826.275 4q12-q13
    GDEP 80967.653 4q21.1
    GNRHR 68285.694 4q21.2
    GRID2 93444.573 4q22
    GRK4 2935.141 4p16.3
    GSTCD 106851.419 4q24
    GSX2 54661.005 4q12
    H2AFZ 101088.267 4q23
    HELT 186177.077 4q35.1
    HERC3 89732.670 4q21
    HERC5 89597.291 4q22.1-q23
    HERC6 89518.915 4q22
    HGFAC 3413.524 4p16
    HHIP 145786.623 4q28-q32
    HMGB2 174489.102 4q31
    HNRNPD 83493.491 4q21
    HNRPDL 83563.371 4q21.22
    HOPX 57208.921 4q12
    HPGD 175647.955 4q34-q35
    HPSE 84435.492 4q21.3
    HSP90AB2P 12944.135 4p15.33
    HSPA4L 128922.903 4q28
    HTRA3 8322.392 4p16.1
    HTT 3046.206 4p16.3
    IBSP 88939.726 4q21-q25
    IGFBP7 57592.001 4q12
    IL15 142777.204 4q31
    IL2 123592.076 4q26-q27
    IL21 123753.233 4q26-q27
    IL8 74825.139 4q13-q21
    ING2 184663.214 4q35.1
    INPP4B 143168.632 4q31.1
    INTS12 106823.234 4q24
    IRF2 185545.870 4q34.1-q35.1
    KCNIP4 20339.337 4p15.32
    KDR 55639.406 4q11-q12
    KLHL2 166348.241 4q21.2
    KLKB1 187385.666 4q35
    LEF1 109188.150 4q23-q25
    LNX1 54021.194 4q12
    LRAT 155884.613 4q31.3
    LRP2BP 186522.027 4q35.1
    MAB21L2 151722.527 4q31
    MANBA 103771.691 4
    MAP2K1IP1 101021.387 4q23
    MAPKSP1 101021.387 4q23
    MED28 17225.371 4p16
    MEPE 88973.164 4q21.1
    METAP1 100135.811 4q23
    MGC16169 107186.687 4q24
    MLF1IP 185852.230 4q35.1
    MMAA 146759.990 4q31.1
    MORF4 174773.662 4q33-q34.1
    MTNR1A 187691.803 4q35.1
    MTTP 100704.263 4q24
    MXD4 2218.958 4p16.3
    MYOZ2 120276.387 4q26-q27
    N4BP2 39734.919 4p14
    NAP1L5 89836.090 4q21-q22
    NARG1 140442.126 4q31.1
    NDST3 119174.948 4q26
    NDST4 115968.376 4q26
    NEIL3 178467.985 4q34
    NEK1 170551.004 4q32.3
    NHEDC2 104166.795 4q24
    NKX6-1 85633.460 4q21.33
    NMU 56156.162 4q12
    NPNT 107036.054 4q25
    NPY1R 164464.567 4q31.3-q32
    NPY2R 156349.231 4q31
    NR3C2 149219.365 4q31.1
    NUDT6 124033.249 4q26
    NUP54 77254.841 4q21.1
    OCIAD1 48527.772 4p11
    ODAM 71096.833 4q13.3
    ODZ3 183482.131 4q35
    PALLD 169654.792 4q32.3
    PAPSS1 108754.271 4q24
    PAQR3 80058.118 4q21
    PCDH10 134289.920 4q28.3
    PCDH7 30331.135 4p15
    PCGF3 689.573 4p16.3
    PDGFC 157902.214 4q32
    PDGFRA 54790.021 4q12
    PDHA2 96980.262 4q22-q23
    PDLIM5 95592.061 4q22
    PDS5A 39500.878 4p14
    PF4 75065.660 4q12-q21
    PHF17 129950.229 4q26-q27
    PHOX2B 41440.856 4p13
    PI4K2B 24844.773 4p15.31
    PITX2 111758.029 4q25
    PKD2 89147.844 4q21-q23
    PLK4 129021.495 4q28
    POLN 2043.443 4p16.3
    POU4F2 147779.495 4q31.22
    PPARGC1A 23402.742 4p15.1
    PPEF2 77000.050 4q21.21
    PPID 159849.729 4q31.3
    PPM1K 89400.556 4q22.1
    PPP2R2C 6373.206 4p16.1
    PPP3CA 102163.610 4q21-q24
    PRDM5 121835.379 4q25-q26
    PRKG2 82228.861 4q13.1-q21.1
    PROM1 15578.955 4p15
    PTTG2 37638.451 4p12
    RAB28 12978.480 4p15.33
    RAB33B 140594.411 4q28
    RAPGEF2 160408.448 4q32.1
    RASGEF1B 82567.243 4
    RASL11B 53423.252 4q12
    RASSF6 74657.726 4q21.1
    RBPJ 25930.430 4p15.2
    REST 57468.799 4q12
    RFC1 38965.471 4p14-p13
    RG9MTD2 100686.907 4q23
    RGS12 3285.672 4p16.3
    RNF150 142006.175 4q31.1
    RNF4 2440.605 4p16.3
    RPL34 109761.171 4q25
    RPS3A 152240.204 4q31.2-q31.3
    SAP30 174528.668 4q34.1
    SCYE1 107457.124 4q24
    SEC31A 83958.838 4q21.3
    SEPT11 78089.919 4q21
    SETD7 140646.642 4q31.1
    SFRP2 154921.192 4q31.3
    SGMS2 109033.879 4q25
    SH3BP2 2764.548 4p16.3
    SLC25A4 186301.392 4q35
    SLC26A1 971.445 4p16.3
    SLC4A4 72271.867 4q21
    SLC7A11 139304.698 4q28-q32
    SLIT2 19864.333 4p15.2
    SMAD1 146623.407 4q31.21
    SMARCA5 144654.066 4q31.1-q31.2
    SMARCAD1 95348.039 4q22-q23
    SNCA 90865.728 4q21
    SOD3 24406.183 4pter-q21
    SPARCL1 88613.512 4q22.1
    SPATA4 177342.719 4q34.2
    SPOCK3 167891.111 4q32.3
    SPON2 1150.721 4p16.3
    SPP1 89115.826 4q21-q25
    SRD5A3 55907.166 4q12
    STAP1 68107.041 4q13.2
    STK32B 5104.428 4p16
    STOX2 185063.503 4q35.1
    SULT1E1 70741.519 4q13.1
    SYT14L 68608.907 4q13.2
    TACC3 1693.064 4p16.3
    TBC1D1 37569.115 4p14
    TEC 47832.556 4p12
    TET2 106287.392 4q24
    THAP9 84040.861 4q21.3
    TLR1 38474.271 4p14
    TLR10 38450.647 4p14
    TLR2 154824.891 4q32
    TLR3 187227.303 4q35
    TLR6 38504.803 4p16.1
    TMEM184C 148757.989 4q31.22
    TMPRSS11A 68458.614 4q13.2
    TNIP2 2713.185 4p16.3
    TRAM1L1 118224.158 4q26
    TRIM60 166172.601 4q32.3
    TRPC3 123019.633 4q27
    TXK 47763.167 4p12
    UBE2D3 103936.217 4q24
    UCHL1 40953.686 4p13
    UGT2B10 69716.318 4q13.3
    UGT2B15 69194.910 4q13
    UGT2B17 69085.498 4q13
    UGT2B7 69996.782 4q13
    UNC5C 96308.712 4q21-q23
    VEGFC 177841.685 4q34.3
    WDR19 38860.419 4p14
    WHSC1 1842.921 4p16.3
    WHSC2 1954.241 4p16.3
    WWC2 184257.457 4q35.1
    ZFP42 189153.919 4q35.2

    GeneCards   GDB - List of genes

    This page should be referenced as such :
    Dessen P, Knuutila S, Huret JL Chromosome 4. Atlas Genet Cytogenet Oncol Haematol. 2002.
    URL : http://AtlasGeneticsOncology.org/Indexbychrom/idxa_4.html
    © Atlas of Genetics and Cytogenetics in Oncology and Haematology
    indexed on : Sat Nov 8 19:45:35 2008
    Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case reports   Journals   Portal   Teaching   

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