| Identity |
| Note | This data is extracted from a very large study from an International Workshop on treatment related leukemias - restricted to balanced chromosome aberrations (i.e.: -5/del(5q)and -7/del(7q) not taken into account per see), published in Genes,Chromosomes and Cancer in 2002. |
| Clinics and Pathology |
| Disease | Treatment related myelodysplasia (t-MDS) or acute non lymphocytic leukaemias (t-ANLL) |
| Note | The study included 9 cases; t-MDS without progression to ANLL accounted for 2 of 9 cases, t-MDS with progression to ANLL for 1 case and t-ANLL for the remaining 6 cases; no case of acute lymphoblastic leukaemia |
| Epidemiology | 12p13 rearrangements were found in 2% of t-MDS/t-ANLL; sex ratio: 5M/4F |
| Clinics | Age at diagnosis of the primary disease 40 yrs (range 11-64); age at diagnosis of the t-MDS/t-ANLL: 48 yrs (range 25-69). Median interval was relatively long: 81 mths (range: 18-223). Primary disease was a solid tumor in only 2 of 9 cases, and a hematologic malignancy in 7/9; treatment was chemotherapy (3/9), or both (6/9). Treatment included topoisomerase II inhibitors in 5 of 9 cases and alkylating agents in 8/9. |
| Prognosis | Median survival was very poor: 4 mths, with 15% of patients surviving at 1 yr, and none at 2 yrs. |
| Cytogenetics |
| Additional anomalies | 12p13 rearrangements included: t(1;12)(q21;p13), t(4;12)(q12;p13), t(7;12)(p15;p13), t(8;12)(p12;p13), t(12;20)p13;q11),and t(12;22)(p13;q11) ID: t(12;22)(p13;q11)> and other rearrangements. Complex karyotypes were found in 7 of 9 cases; -7/del(7q) and/or |
| Result of the chromosomal anomaly |
| Description | 5' ETV6 -3¹ partner where ETV6 is known to be involved |
| Bibliography |
| Rare recurring balanced chromosome abnormalities in therapy-related myelodysplastic syndromes and acute leukemia: report from an international workshop. |
| Block AW, Carroll AJ, Hagemeijer A, Michaux L, van Lom K, Olney HJ, Baer MR |
| Genes, chromosomes & cancer. 2002 ; 33 (4) : 401-412. |
| PMID 11921274 |
| Contributor(s) |
| Written | 10-2003 | Jean-Loup Huret |
| Citation |
| This paper should be referenced as such : |
| Huret JL . 12p13 rearrangements in treatment related leukemia. Atlas Genet Cytogenet Oncol Haematol. October 2003 . URL : http://AtlasGeneticsOncology.org/Anomalies/12p13TreatRelLeukID1301.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Mon May 12 18:11:07 2008 |
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