| Disease | acute lyphocytic leukemia (ALL) |
| Phenotype / cell stem origin | lack of specificity for particular immunophenotype, although more stem origin frequent in B-lineage cases |
| Epidemiology | approximately 10-15% of pediatric ALL cases, and 5% of adult ALL |
| Prognosis | recent data indicate no difference in overall outcome between childhood ALL cases with versus without 12p abnormalities, although there was an improved outcome for pseudodiploid patients with versus without a cytogenetic 12p abnormality; although a dic(9;12) has been reported to be associated with an excellent outcome, in a recent study, there was no difference in outcome between those patients with a dic(9;12) versus patients lacking an abnormal 12p. |
| Dicentric (9;12) in acute lymphocytic leukemia and other hematological malignancies: report from a dic(9;12) study group. |
| Behrendt H, Charrin C, Gibbons B, Harrison CJ, Hawkins JM, Heerema NA, Horschler-Bˆtel B, Huret JL, LaˆØ JL, Lampert F |
| Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 1995 ; 9 (1) : 102-106. |
| PMID 7845002 |
| |
| Cytogenetic abnormalities in adult acute lymphoblastic leukemia: correlations with hematologic findings outcome. A Collaborative Study of the Group Franˆßais de Cytogˆ©nˆ©tique Hˆ©matologique. |
| Blood. 1996 ; 87 (8) : 3135-3142. |
| PMID 8605327 |
| |
| Cytogenetics and prognosis in childhood lymphoblastic leukaemia: results of MRC UKALL X. Medical Research Council Working Party in Childhood Leukaemia. |
| Chessels JM, Swansbury GJ, Reeves B, Bailey CC, Richards SM |
| British journal of haematology. 1997 ; 99 (1) : 93-100. |
| PMID 9359508 |
| |
| 12p abnormalities and the TEL gene (ETV6) in childhood acute lymphoblastic leukemia. |
| Raimondi SC, Shurtleff SA, Downing JR, Rubnitz J, Mathew S, Hancock M, Pui CH, Rivera GK, Grosveld GC, Behm FG |
| Blood. 1997 ; 90 (11) : 4559-4566. |
| PMID 9373267 |
| |
