| Identity |
| Note | Deletions of chromosome 13q are a non-random finding in a broad spectrum of haematological neoplasms, including B-cell chronic lymphocytic leukemia (CLL), non-Hodgkin's lymphoma (NHL) and multiple myeloma (MM) and |
| Clinics and Pathology |
| Disease | Acute lymphoblastic leukaemia (ALL) |
| Phenotype / cell stem origin | No specific immunophenotype observed |
| Epidemiology | A del(13q) chromosome is found in approximately 2% of cases in both adult and childhood disease at presentation. Up to 4% of cases may have some loss of 13q material, either through full monosomy or unbalanced rearrangements. Incidence of chromosome 13 deletions is higher at relapse. |
| Prognosis | May confer an increased risk of treatment failure but to date has not been shown to be an independent prognostic indicator. |
| Cytogenetics |
| Cytogenetics Morphological | Various breakpoints reported. The centromeric breakpoint is typically in the 13q12-14 region and telomeric between 13q21 and 13qter. Loss of all or part of 13q14 is common to almost all cases. Occurs as a sole event in approximately 10% of cases. There are also rare reports of translocations also leading to a partial 13q deletion. Monosomy 13 is also reported but occurs very rarely as a sole aberration. Under representation of chromosome 13 is often found in hypotriploid cases. |
| Additional anomalies | Most cases with del(13q) will have additional aberrations, but there is no consistent picture and the events can include the typical non-random events in ALL. |
| Genes involved and Proteins |
| Note | Critical region in 13q14 appears to lie telomeric to RB1. |
| External links |
| Other database | del(13q) in ALL | Mitelman database (CGAP - NCBI) |
| Bibliography |
| Deletions in the 13q14 locus in adult lymphoblastic leukemia: rate of incidence and relevance. |
| Chung CY, Kantarjian H, Haidar M, Starostik P, Manshouri T, Gidel C, Freireich E, Keating M, Albitar M |
| Cancer. 2000 ; 88 (6) : 1359-1364. |
| PMID 10717617 |
| Abnormalities of chromosome bands 13q12 to 13q14 in childhood acute lymphoblastic leukemia. |
| Heerema NA, Sather HN, Sensel MG, Lee MK, Hutchinson RJ, Nachman JB, Reaman GH, Lange BJ, Steinherz PG, Bostrom BC, Gaynon PS, Uckun FM |
| Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2000 ; 18 (22) : 3837-3844. |
| PMID 11078497 |
| New recurring cytogenetic abnormalities and association of blast cell karyotypes with prognosis in childhood T-cell acute lymphoblastic leukemia: a pediatric oncology group report of 343 cases. |
| Schneider NR, Carroll AJ, Shuster JJ, Pullen DJ, Link MP, Borowitz MJ, Camitta BM, Katz JA, Amylon MD |
| Blood. 2000 ; 96 (7) : 2543-2549. |
| PMID 11001909 |
| Deletion of chromosomal region 13q14.3 in childhood acute lymphoblastic leukemia. |
| Cavˆ© H, Avet-Loiseau H, Devaux I, Rondeau G, Boutard P, Lebrun E, Mˆ©chinaud F, Vilmer E, Grandchamp B |
| Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 2001 ; 15 (3) : 371-376. |
| PMID 11237059 |
| Aberrations involving 13q12 approximately q14 are frequent secondary events in childhood acute lymphoblastic leukemia. |
| Kovacs BZ, Niggli FK, Betts DR |
| Cancer genetics and cytogenetics. 2004 ; 151 (2) : 157-161. |
| PMID 15172754 |
| Contributor(s) |
| Written | 11-2004 | David Betts |
| Department of Oncology, University Children's Hospital, Steinwiesstr. 75, CH-8032 Zürich, Switzerland |
| Citation |
| This paper should be referenced as such : |
| Betts D . del(13q) in ALL. Atlas Genet Cytogenet Oncol Haematol. November 2004 . URL : http://AtlasGeneticsOncology.org/Anomalies/del13qALLID1188.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Sat Feb 6 15:45:04 CET 2010 |
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