| Clinics and Pathology |
| Disease | acute lymphoblastic leukaemia (ALL) |
| Phenotype / cell stem origin | early B-lineage ALL |
| Prognosis | remission rates are high although long term prognosis is not yet established |
| Cytogenetics |
| Cytogenetics Morphological | dic(9;20)(p11-13;q11) is a subtle chromosome abnormality, often appearing as monosomy 20, sometimes with apparent deletion of 9p; confirmation of the dic(9;20) translocation is obtained by FISH |
| Additional anomalies | multiple chromosome abnormalities may be present in addition to the dic(9;20);trisomy 21 is the most frequent secondary abnormality |
| Bibliography |
| dic(9;20): a new recurrent chromosome abnormality in adult acute lymphoblastic leukemia. |
| Rieder H, Schnittger S, Bodenstein H, Schwonzen M, Wˆrmann B, Berkovic D, Ludwig WD, Hoelzer D, Fonatsch C |
| Genes, chromosomes & cancer. 1995 ; 13 (1) : 54-61. |
| PMID 7541644 |
| A non-random chromosome abnormality found in precursor-B lineage acute lymphoblastic leukaemia: dic(9;20)(p1?3;q11). |
| Slater R, Smit E, Kroes W, Bellomo MJ, Mˆºhlematter D, Harbott J, Behrendt H, Hˆ§hlen K, Veerman AJ, Hagemeijer A |
| Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 1995 ; 9 (10) : 1613-1619. |
| PMID 7564498 |
| Dicentric (9;20)(p11;q11) identified by fluorescence in situ hybridization in four pediatric acute lymphoblastic leukemia patients. |
| Heerema NA, Maben KD, Bernstein J, Breitfeld PP, Neiman RS, Vance GH |
| Cancer genetics and cytogenetics. 1996 ; 92 (2) : 111-115. |
| PMID 8976366 |
| Contributor(s) |
| Written | 06-1999 | Barbara Gibbons |
| NE London Regional Cytogenetics Laboratory 2nd Floor, Queen Square House Institute of Neurology Queen Square London WC1N 3BG, UK |
| Citation |
| This paper should be referenced as such : |
| Gibbons B . dic(9;20)(p11-13;q11). Atlas Genet Cytogenet Oncol Haematol. June 1999 . URL : http://AtlasGeneticsOncology.org/Anomalies/dic920ID1143.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Mon May 12 18:11:39 2008 |
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