| Clinics and Pathology |
| Disease | T cell acute lymphocytic leukaemia (T-ALL) |
| Clinics | yet poorly known: only 1 case: a young adult male patient with high WBC (common features in T-ALL); bone marrow transplantation; complete remission: 43 mths + |
| Genes involved and Proteins |
| Gene Name | TAL1 |
| Location | 1p32 |
| Dna / Rna | complex alternate splicing |
| Protein | contains a basic Helix-Loop-Helix (DNA binding) domain; forms heterodimers; transcription factor; role in haematopoietic cell differentiation |
| Gene Name | yet unknown gene |
| Location | 5q31 |
| Result of the chromosomal anomaly |
| Description | breakpoint on TAL1 was found 10kb upstream the gene, as was found in the cases of t(1;3)(p32;p21), while it is more 3', within the gene, in the t(1;14)(p32;q11) and in TAL1 deletions. |
| External links |
| Other database | t(1;5)(p32;q31) | Mitelman database (CGAP - NCBI) | |
| Other database | t(1;5)(p32;q31) | CancerChromosomes (NCBI) |
| To be noted |
| Additional cases are needed to delineate the epidemiology of this rare entity: you are welcome to submit a paper to our new Case Report section. |
| Bibliography |
| Deregulated expression of the TAL1 gene by t(1;5)(p32;31) in patient with T-cell acute lymphoblastic leukemia. |
| Franˆßois S, Delabesse E, Baranger L, Dautel M, Foussard C, Boasson M, Blanchet O, Bernard O, Macintyre EA, Ifrah N |
| Genes, chromosomes & cancer. 1998 ; 23 (1) : 36-43. |
| PMID 9713995 |
| Contributor(s) |
| Written | 09-1998 | Jean-Loup Huret |
| Citation |
| This paper should be referenced as such : |
| Huret JL . t(1;5)(p32;q31). Atlas Genet Cytogenet Oncol Haematol. September 1998 . URL : http://AtlasGeneticsOncology.org/Anomalies/t0105ID1141.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Mon May 12 18:11:50 2008 |
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