t(1;7)(q10;p10)

Identity

	der(7)t(1;7)(p10;q10) G- (left) and R- (right) bandings – top: Courtesy Jean-Luc Lai; middle and bottom: - Courtesy Diane H. Norback, Eric B. Johnson, and Sara Morrison-Delap, UW Cytogenetic Services

Clinics and Pathology

Disease	Myelodysplasic syndromes (MDS) in 60 % of cases, often evolving towards acute non lymphoblastic leukaemia (ANLL); ANLL in 30%, frequently with preceeding MDS; these MDS or ANLL are therapy-related (secondary to toxic exposure) in half cases; myeloproliferative diseases (MPD) represent the remaining 10% of cases
Phenotype / cell stem origin	MDS cases: often RAEB±T or RA; ANLL: M4 or M1; MPD cases: myelofibrosis
Epidemiology	represent 3-7 % of secondary leukaemias, 0.5% and 2% of de novo ANLL and MDS respectively; adults mostly (median 60 yrs; only a very few children cases); male predominance (3M/2F), but secondary leukaemias cases are more frequently female cases (presence of uncovered environmental genotoxic factors in male cases ?).
Prognosis	poor prognosis; median survival was reviewed in 1992 and was found to be of 11 mths; male sex, a low haemoglobin level may be adverse prognostic features; prognosis is better, obviously in case of a MPD.

Cytogenetics

Cytogenetics Morphological	whole-arm translocation of 7p with 1q; most often unbalanced (-7, +t(1;7)) --> trisomy for 1q / monosomy for 7q; may therefore represent an equivalent to del(7q).
Probes	centromeric probes
Additional anomalies	sole anomaly in half; hyperploidy in 1/3 of cases; +8 (20%); +21 (10%); +9; additional structural abnormalities in 15%

External links

Other database	t(1;7)(q10;p10)	Mitelman database (CGAP - NCBI)
Other database	t(1;7)(q10;p10)	CancerChromosomes (NCBI)

Bibliography

An identical translocation between chromosome 1 and 7 in three patients with myelofibrosis and myeloid metaplasia.

Geraedts JP, den Ottolander GJ, Ploem JE, Muntinghe OG

British journal of haematology. 1980 ; 44 (4) : 569-575.

PMID 7378317

Translocation t(1;7) revisited. Report of three further cases and review.

Willem P, Pinto M, Bernstein R

Cancer genetics and cytogenetics. 1988 ; 36 (1) : 45-54.

PMID 3060251

The unbalanced 1;7 translocation in de novo myelodysplastic syndrome and its clinical implication.

Horiike S, Taniwaki M, Misawa S, Nishigaki H, Okuda T, Yokota S, Kashima K, Inazawa J, Abe T

Cancer. 1990 ; 65 (6) : 1350-1354.

PMID 2306683

Cytogenetics of secondary myelodysplasia (sMDS) and acute nonlymphocytic leukemia (sANLL).

Johansson B, Mertens F, Heim S, Kristoffersson U, Mitelman F

European journal of haematology. 1991 ; 47 (1) : 17-27.

PMID 1868912

Survival of patients with t(1;7)(p11;p11). Report of two cases and review of the literature.

Pedersen B

Cancer genetics and cytogenetics. 1992 ; 60 (1) : 53-59.

PMID 1591707

Contributor(s)

Written	11-1998	Jean-Loup Huret

Citation

This paper should be referenced as such :

Huret JL . t(1;7)(q10;p10). Atlas Genet Cytogenet Oncol Haematol. November 1998 . URL : http://AtlasGeneticsOncology.org/Genes/t0107ID1003.html

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Mon Aug 11 21:19:38 2008

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