| Clinics and Pathology |
| Disease | Follicular lymphoma in one CD10+ case, but without a t(14;18)(q32;q21), bcl2 negative, and with a t(1;14)(q21;q32); follicular lymphoma with FCGR2B rearrangement and dup(1)(q21q25)in another case . |
| Epidemiology | These two cases with FCGR2B rearrangement were found among a panel of 76 non Hodgkin's lymphomas. |
| Prognosis | May be associated with tumor progression. |
| Cytogenetics |
| Cytogenetics Morphological | One case with 46, XX, t(1;14)(q21;q32), t(8;9)(q24;q13); progression to a diffuse large cells lymphoma with a complexe caryotype. An another case with FCGR2B rearrangement in a follicular lymphoma: the karyotype was complexe with dup(1)(q21q25), t(14;18)(q32;q21). |
| Genes involved and Proteins |
| Gene Name | FCGR2B |
| Location | 1q22 |
| Gene Name | IgH |
| Location | 14q32 |
| Result of the chromosomal anomaly |
| Description | The translocation juxtapose the 5' switch region og IGHG2 to a region upstream of FCGR2B in the der(1) chromosome.FCGR2B is deregulated by this translocation and FCGR2B b2 mRNA isoform is overexpressed. |
| Note | No fusion protein. |
| Oncogenesis | It is possible that alteration in the b2/b1 mRNA isoforms ratio in B-cells may promote B cell survival. This anomaly is bcl2 deregulation-independant because FCGR2B has been shown to be a tumor-enhancing factor in non lymphoid cells in murine in vivo and in vitro models. Deregulation of FCGR2B expression can be considered as a second event which may impart additional growth advantage to the bcl2 deregulated B-cells. |
| External links |
| Other database | t(1;14)(q21;q32) FCGR2B/IGH | Mitelman database (CGAP - NCBI) | |
| Other database | t(1;14)(q21;q32) FCGR2B/IGH | CancerChromosomes (NCBI) |
| To be noted |
| Additional cases are needed to delineate the epidemiology of this rare entity: you are welcome to submit a paper to our new Case Report section. |
| Bibliography |
| Deregulation of FCGR2B expression by 1q21 rearrangements in follicular lymphomas. |
| Chen W, Palanisamy N, Schmidt H, Teruya-Feldstein J, Jhanwar SC, Zelenetz AD, Houldsworth J, Chaganti RS |
| Oncogene. 2001 ; 20 (52) : 7686-7693. |
| PMID 11753646 |
| Non-Hodgkin's Lymphoma: Molecular Features of B Cell Lymphoma. |
| Macintyre E, Willerford D, Morris SW |
| Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program. 2000 : 180-204. |
| PMID 11701542 |
| The IgG Fc receptor, FcgammaRIIB, is a target for deregulation by chromosomal translocation in malignant lymphoma. |
| Callanan MB, Le Baccon P, Mossuz P, Duley S, Bastard C, Hamoudi R, Dyer MJ, Klobeck G, Rimokh R, Sotto JJ, Leroux D |
| Proceedings of the National Academy of Sciences of the United States of America. 2000 ; 97 (1) : 309-314. |
| PMID 10618414 |
| Contributor(s) |
| Written | 02-2005 | Jacques Boyer |
| Laboratoire d' hématologie, CH du MANS, France |
| Citation |
| This paper should be referenced as such : |
| Boyer J . t(1;14)(q21;q32) FCGR2B/IGH. Atlas Genet Cytogenet Oncol Haematol. February 2005 . URL : http://AtlasGeneticsOncology.org/Genes/t0114q21q32ID1341.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Wed Sep 24 21:06:16 2008 |
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