| Disease | Only two cases of hematological malignancy with der(1;18) are reported in the literature. In both instances der(1;18) occurs as the sole karyotypic abnormality. They are found in two patients suffering from myeloid disorders. |
| Phenotype / cell stem origin | Unknown, but may involve a myeloid progenitor cell as both reported cases can be grouped under myeloid malignancy |
| Clinics | The first case was a 23-year old male who presented as myelodysplastic syndrome that rapidly progressed to acute myeloid leukemia, and died of neutropenic sepsis at induction phase. The second case was a 65-year old female diagnosed as chronic myeloproliferative disorder, unclassifiable, and run a chronic stable clinical course for years. She however suffered from recurrent pyogenic cutaneous infection |
| Prognosis | Owing to the small number of cases reported, the prognostic implication of der(1;18)(q10;q10) remains to be defined. The clinical outcome of the two reported cases were markedly different, with one having rapid downhill course and short survival whereas the other one having chronic disease again if necessary |
| Robertsonian translocation as an acquired karyotypic abnormality in leukaemia. |
| Ma SK, Chow EY, Wan TS, Chan LC |
| British journal of haematology. 1997 ; 98 (1) : 213-215. |
| PMID 9233587 |
| |
| Derivative (1;18)(q10;q10): a recurrent and novel unbalanced translocation involving 1q in myeloid disorders. |
| Wan TS, Ma SK, Au WY, Chan LC |
| Cancer genetics and cytogenetics. 2001 ; 128 (1) : 35-38. |
| PMID 11454427 |
| |
