| Clinics and Pathology |
| Disease | Acute myeloid leukaemia (AML) |
| Epidemiology | only one case to date, a 1 year old boy with M1 AML |
| Prognosis | no data |
| Genes involved and Proteins |
| Gene Name | ZNF687 |
| Location | 1q21 |
| Protein | 10 zinc fingers; krueppel C2H2-type zinc-finger protein; transcription factor |
| Gene Name | RUNX1 |
| Location | 21q22 |
| Protein | Transcription factor (activator) for various hematopoietic-specific genes, which experssion is limited to hematopoetic stem cells, and endothelial cells and mesenchymal cells in the embryo; core binding factor family member which forms heterodimers with CBFB; binds to the core site 5' PyGPyGGTPy 3' of promotors and enhancers |
| Result of the chromosomal anomaly |
| Description | 5' RUNX1- 3' ZNF687 |
| External links |
| Other database | t(1;21)(q21;q22) | Mitelman database (CGAP - NCBI) | |
| Other database | t(1;21)(q21;q22) | CancerChromosomes (NCBI) |
| To be noted |
| Additional cases are needed to delineate the epidemiology of this rare entity: you are welcome to submit a paper to our new Case Report section. |
| Bibliography |
| Identification of novel Runx1 (AML1) translocation partner genes SH3D19, YTHDf2, and ZNF687 in acute myeloid leukemia. |
| Nguyen TT, Ma LN, Slovak ML, Bangs CD, Cherry AM, Arber DA |
| Genes, chromosomes & cancer. 2006 ; 45 (10) : 918-932. |
| PMID 16858696 |
| Contributor(s) |
| Written | 09-2007 | Jean-Loup Huret |
| Jean Loup HURET, Genetics, Dept Medical Information, University of Poitiers; CHU Poitiers Hospital, F-86021 Poitiers, France |
| Citation |
| This paper should be referenced as such : |
| Huret JL . t(1;21)(q21;q22). Atlas Genet Cytogenet Oncol Haematol. Septem
ber 2007 . URL : http://AtlasGeneticsOncology.org/Genes/t0121q21q22ID1446.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Wed Sep 24 21:06:21 2008 |
For comments and suggestions or contributions, please contact us