t(2;11)(p21;q23)

Identity

	t(2;11)(p21;q23) R- banding (Editor)

Clinics and Pathology

Disease	myelodysplastic syndromes (MDS), acute non lymphocytic leukemia (ANLL) and acute lymphoblastic leukemia (ALL)
Phenotype / cell stem origin	20 cases were documented, 14 of them were MDS; in three cases, type of MDS was not described; the remaining cases were: 2 AISA, 5 RA and 4 RAEB; in 6 patients, MDS has transformed into ANLL (M1, M5a, M6 and unidentified); in 6 cases acute leukemia was diagnosed : 4 ANLL, 2 ALL; ANLL FAB-types were: M0 evolving into M4, M1, M2 and atypical M3
Epidemiology	male predominance: 13 M:7 F; the majority of patients (16 out of 20) were over 50 years of age and 8 of them were over 60 years of age
Clinics	variable
Prognosis	due to heterogeneity of cases and lack of molecular data, the prognostic importance of t(2;11)(p21;q23) cannot be assessed; in 6 cases of MDS transformation into ANLL, MDS phase varied from 18 mths to 5 yrs; in 4 out of 5 ANLL cases treated in 1986-1993, remission duration varied from 6 to 13 mths

Cytogenetics

Cytogenetics Morphological	a high variability of breakpoints on both chromosome 2 (2p16-2p21) and chromosome 11 (11q13-11q25) were found by conventional cytogenetics
Cytogenetics Molecular	MLL gene involvement was observed in 2 out of 3 cases studied
Additional anomalies	additional abnormalities were observed in 10 out of 20 cases; in 8 cases, del(5)(q13q33) is found; it is of note, that deletions of 5q usually are not seen in cases with MLL-associated translocations

Genes involved and Proteins

Note	the gene involved in 2p in unknown

Gene Name	MLL
Location	11q23
Dna / Rna	37 exons, spanning about 120 kb; 13-15 mRNA
Protein	431 kD; transcriptional regulatory factor, nuclear localization; Contains two DNA binding motifs (a AT hook and zinc fingers), a DNA methyl transferase motif

Result of the chromosomal anomaly

Hybrid gene

Description	unknown

Fusion Protein

Description	unknown

External links

Other database	t(2;11)(p21;q23)	Mitelman database (CGAP - NCBI)
Other database	t(2;11)(p21;q23)	CancerChromosomes (NCBI)

Bibliography

A 2p;11q chromosome translocation in dysmyelopoietic preleukemia.

Feder M, Finan J, Besa E, Nowell P

Cancer genetics and cytogenetics. 1985 ; 15 (1-2) : 143-150.

PMID 3967213

Translocation (2;11) (p21;q23) in acute non-lymphocytic leukaemia: a non-random association.

de la Chapelle A, Knuutila S, Elonen E

Scandinavian journal of haematology. Supplementum. 1986 ; 45 : 91-97.

PMID 3457447

Rearrangement of the MLL gene in acute lymphoblastic and acute myeloid leukemias with 11q23 chromosomal translocations.

Thirman MJ, Gill HJ, Burnett RC, Mbangkollo D, McCabe NR, Kobayashi H, Ziemin-van der Poel S, Kaneko Y, Morgan R, Sandberg AA

The New England journal of medicine. 1993 ; 329 (13) : 909-914.

PMID 8361504

MLL is involved in a t(2;11)(p21;q23) in a patient with acute myeloblastic leukemia.

Fleischman EW, Reshmi S, Frenkel MA, Konovalova WI, Guleva GP, Kulagina OE, Konstantinova LN, Tupitsyn NN, Rowley JD

Genes, chromosomes & cancer. 1999 ; 24 (2) : 151-155.

PMID 9885982

Contributor(s)

Written	01-2000	Elena W Fleischman
		Cancer Research Center, Moscow, Russia

Citation

This paper should be referenced as such :

Fleischman EW . t(2;11)(p21;q23). Atlas Genet Cytogenet Oncol Haematol. January 2000 . URL : http://AtlasGeneticsOncology.org/Anomalies/t0211ID1109.html

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Mon May 12 18:12:04 2008

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