| Clinics and Pathology |
| Disease | Acute myeloid leukaemia (AML) |
| Phenotype / cell stem origin | One de novo AML (M2 type), and a therapy related AML (t-AML) |
| Epidemiology | The de novo AML was a 11 year old girl; the t-AML case was a 58 year old female patient who had been treated for ovary carcinoma with melphalan 1.5 yrs before. |
| Prognosis | No complete remission (CR) in the de novo case; CR was obtained but a relapse occurred and the patient died 3 months after diagnosis in the therapy related case. |
| Cytogenetics |
| Cytogenetics Morphological | Sole anomaly in the de novo AML case; complex karyotype in the t-AML case, with -5 and other abnormalities |
| Genes involved and Proteins |
| Note | Genes involved are unknown. |
| External links |
| Other database | t(2;19)(p11;p13) | Mitelman database (CGAP - NCBI) | |
| Other database | t(2;19)(p11;p13) | CancerChromosomes (NCBI) |
| To be noted |
| Additional cases are needed to delineate the epidemiology of this rare entity: you are welcome to submit a paper to our new Case Report section. |
| Bibliography |
| Short remission durations in therapy-related leukemia despite cytogenetic complete responses to high-dose cytarabine. |
| Larson RA, Wernli M, Le Beau MM, Daly KM, Pape LH, Rowley JD, Vardiman JW |
| Blood. 1988 ; 72 (4) : 1333-1339. |
| PMID 3167210 |
| Translocation t(2;19)(p11;p12-p13) in childhood with acute myeloid leukemia. |
| Quilichini B, Zattara H, Cas E, BastideAlliez LA, Blachere A, Curtillet C, Fossat C, Michel G |
| Atlas Genet Cytogenet Oncol Haematol. 2003 ; 7 (numero 1) : 137-140. |
| Contributor(s) |
| Written | 08-2007 | Jean-Loup Huret |
| Jean Loup HURET, Genetics, Dept Medical Information, University of Poitiers; CHU Poitiers Hospital, F-86021 Poitiers, France |
| Citation |
| This paper should be referenced as such : |
| Huret JL . t(2;19)(p11;p13). Atlas Genet Cytogenet Oncol Haematol. August 2007 . URL : http://AtlasGeneticsOncology.org/Anomalies/t0219p11p13ID1288.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Mon May 12 18:12:07 2008 |
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