Atlas of Genetics and Cytogenetics in Oncology and Haematology
t(3;5)(q25;q34)
| Identity |
 | |
| t(3;5)(q25;q34) (R-banding) - Courtesy Jacques Boyer | |
| Clinics and Pathology |
| Disease | myeloproliferative disorders (MPS), myelodysplastic syndromes (MDS), and acute non lymphocytic leukemia (ANLL) |
| Phenotype / cell stem origin | M2, M4, M6 ANLL; trilineage involvement |
| Epidemiology | median age: 35 yrs; balanced sex ratio |
| Prognosis | CR: 8/12, but median survival is less than 1 yr |
| Cytogenetics |
| Cytogenetics Morphological | The breakpoints (3q25 and 5q34) have been controversial for a long time. |
| Additional anomalies | most often none; +8 |
| Genes involved and Proteins |
| Gene Name | MLF1 |
| Location | 3q25 |
| Protein | 31 KDa; widely expressed; cytoplasmic localisation; possible role in normal hematopoietic differentiation |
| Gene Name | NPM1 |
| Location | 5q34 |
| Protein | nuclear localisation; binds to single and double strand nucleic acids; phosphoprotein that may transport ribonucleoproteins; may also have a role in DNA replication nuclear phosphoprotein; role in centrosome duplication and various relations with other proteins like p53, ARF, ... (numerous interations are under study). |
| Result of the chromosomal anomaly |
| Description | 5' NPM-3' MLF1 on der(5) |
| Description | 54 kDa with the 175 N-term Amino acids from NPM |
| Expression Localisation | nucleus, mainly in the nucleolus |
| External links |
| Other database | t(3;5)(q25;q34) | Mitelman database (CGAP - NCBI) | |
| Other database | t(3;5)(q25;q34) | CancerChromosomes (NCBI) |
| Bibliography |
| Clinical, haematological and cytogenetic features in 24 patients with structural rearrangements of the Q arm of chromosome 3. |
| Grigg AP, Gascoyne RD, Phillips GL, Horsman DE |
| British journal of haematology. 1993 ; 83 (1) : 158-165. |
| PMID 8435325 |
| The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1. |
| Yoneda-Kato N, Look AT, Kirstein MN, Valentine MB, Raimondi SC, Cohen KJ, Carroll AJ, Morris SW |
| Oncogene. 1996 ; 12 (2) : 265-275. |
| PMID 8570204 |
| Clinicopathologic manifestations and breakpoints of the t(3;5) in patients with acute nonlymphocytic leukemia. |
| Raimondi SC, Dubˆ© ID, Valentine MB, Mirro J Jr, Watt HJ, Larson RA, Bitter MA, Le Beau MM, Rowley JD |
| Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 1989 ; 3 (1) : 42-47. |
| PMID 2642576 |
| Detection of NPM/MLF1 fusion in t(3;5)-positive acute myeloid leukemia and myelodysplasia. |
| Arber DA, Chang KL, Lyda MH, Bedell V, Spielberger R, Slovak ML |
| Human pathology. 2003 ; 34 (8) : 809-813. |
| PMID 14506644 |
| Contributor(s) |
| Written | 08-1997 | Jean-Loup Huret |
| Updated | 10-2004 | Roland Berger |
| Citation |
| This paper should be referenced as such : |
| Huret JL . t(3;5)(q25;q34). Atlas Genet Cytogenet Oncol Haematol. August 1997 . URL : http://AtlasGeneticsOncology.org/Anomalies/t0305.html |
| Berger R . t(3;5)(q25;q34). Atlas Genet Cytogenet Oncol Haematol. October 2004 . URL : http://AtlasGeneticsOncology.org/Anomalies/t0305.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Sat Feb 6 15:45:39 CET 2010 |
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