| Clinics and Pathology |
| Disease | treatment related acute non lymphocytic leukemia (t-ANLL) so far |
| Epidemiology | only 1 case available |
| Clinics | a 41 yr old female patient with a previous history of non Hodgkin lymphoma treated withtopoisomerase II inhibitors 3 yrs earlier; she developped a M5a t-ANLL and died 10 days after diagnosis |
| Cytogenetics |
| Additional anomalies | a complex karyotype was found in the only available case, with +8 and other anomalies. |
| Genes involved and Proteins |
| Gene Name | LPP |
| Location | 3q28 |
| Protein | LPP is a member of the LIM protein gene family, containing a leucin-zipper motif in its amino-terminal region and three LIM domains in its carboxy-terminal region |
| Gene Name | MLL |
| Location | 11q23 |
| Protein | contains two DNA binding motifs (a AT hook, and Zinc fingers), a DNA methyl transferase motif, a bromodomain; transcriptional regulatory factor involved in maintenance of Hox gene expression |
| Result of the chromosomal anomaly |
| Description | 5' MLL including the 8 first exons fused to the 3 last 3' exons (exons 9 to 11) of LPP. |
| Transcript | the reciprocal 5'MLPP-3'MLL is also transcribed |
| Description | N-term AT hook and DNA methyltransferase from MLL fused to the 2 last C-term LIM domains of LPP |
| External links |
| Other database | t(3;11)(q28;q23) | Mitelman database (CGAP - NCBI) | |
| Other database | t(3;11)(q28;q23) | CancerChromosomes (NCBI) |
| To be noted |
| Additional cases are needed to delineate the epidemiology of this rare entity: you are welcome to submit a paper to our new Case Report section. |
| Bibliography |
| Human LPP gene is fused to MLL in a secondary acute leukemia with a t(3;11) (q28;q23). |
| Dahˆ©ron L, Veinstein A, Brizard F, Drabkin H, Lacotte L, Guilhot F, Larsen CJ, Brizard A, Roche J |
| Genes, chromosomes & cancer. 2001 ; 31 (4) : 382-389. |
| PMID 11433529 |
| Contributor(s) |
| Written | 10-2001 | Jean-Loup Huret |
| Citation |
| This paper should be referenced as such : |
| Huret JL . t(3;11)(q28;q23). Atlas Genet Cytogenet Oncol Haematol. October 2001 . URL : http://AtlasGeneticsOncology.org/Anomalies/t0311q28q23ID1223.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Mon May 12 18:12:13 2008 |
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