Atlas of Genetics and Cytogenetics in Oncology and Haematology
t(3;13)(q27;q14)
| Identity |
 | |
| t(3,13)(q27; q14-21), t(14;18;(q32;q21) G - banding - Courtesy Jean-Luc Lai | |
| Clinics and Pathology |
| Disease | NHL |
| Phenotype / cell stem origin | found in various types of NHL (e.g. Burkitt's lymphoma and follicular lymphoma); the translocation is therefore likely to be a secondary event in the course of the disease. |
| Epidemiology | only 3 cases available to date; all three are adult female patients |
| Cytogenetics |
| Cytogenetics Morphological | found twice (out of three occurrence) as a secondary anomaly: following the well known t(8;14)(q24;q32) and t(14;18)(q32;q21) |
| Additional anomalies | del(6q) found in 2 of 3 cases; the karyotype may be complex |
| Genes involved and Proteins |
| Gene Name | BCL6 |
| Location | 3q27 |
| Gene Name | L-plastin |
| Location | 13q14-21 |
| External links |
| Other database | t(3;13)(q27;q14) | Mitelman database (CGAP - NCBI) | |
| Other database | t(3;13)(q27;q14) | CancerChromosomes (NCBI) |
| To be noted |
| Additional cases are needed to delineate the epidemiology of this rare entity: you are welcome to submit a paper to our new Case Report section. |
| Bibliography |
| Translocation (3;13)(q27;q14): a nonrandom and probably secondary structural change in non-Hodgkin lymphomas. |
| LaˆØ JL, Daudignon A, Kerckaert JP, Galiˆ®gue-Zouitina S, Detourmignies L, Morel P, Bauters F, Fenaux P |
| Cancer genetics and cytogenetics. 1998 ; 103 (2) : 140-143. |
| PMID 9614913 |
| Contributor(s) |
| Written | 01-1998 | Jean-Loup Huret and Jean-Luc Laï |
| Citation |
| This paper should be referenced as such : |
| Huret JL and Laï JL . t(3;13)(q27;q14). Atlas Genet Cytogenet Oncol Haematol. January 1998 . URL : http://AtlasGeneticsOncology.org/Genes/t0313.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Mon Aug 11 21:20:01 2008 |
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