| Clinics and Pathology |
| Disease | B cell non Hodgkin lymphoma (NHL) |
| Epidemiology | Only 3 cases so far |
| Clinics | The 3 patients had diffuse large B cell lymphoma (DLBCL); 2 of 2 patients were male patients, one presented with a history of follicular small cleaved cell lymphoma 15 yrs ago, when aged 47 yr. This patient died 6 mths later of progressive disease. |
| Cytogenetics |
| Additional anomalies | 2 out of 2 cases had a t(14;18)(q32;q21) and both patients presented with MAKA (major karyotypic anomalies) |
| Genes involved and Proteins |
| Gene Name | BCL6 |
| Location | 3q27 |
| Dna / Rna | spans on 25 kb;. 11 exons |
| Protein | Sequence-specific DNA binding transcriptional repressor |
| Gene Name | MHC2TA |
| Location | 16p13 |
| Protein | Non-DNA-binding transcriptional coactivator; transactivator of the major histocompatibility complex (MHC) class II genes |
| Result of the chromosomal anomaly |
| Description | 5'-MHC2TA/BCL6-3' fusion transcripts but also the 5'-BCL6/MHC2TA-3' fusion transcripts, |
| External links |
| Other database | t(3;16)(q27;p13) | Mitelman database (CGAP - NCBI) | |
| Other database | t(3;16)(q27;p13) | CancerChromosomes (NCBI) |
| To be noted |
| Additional cases are needed to delineate the epidemiology of this rare entity: you are welcome to submit a paper to our new Case Report section. |
| Bibliography |
| Concurrent chromosomal alterations at 3q27, 8q24 and 18q21 in B-cell lymphomas. |
| Au WY, Gascoyne RD, Viswanatha DS, Skinnider BF, Connors JM, Klasa RJ, Horsman DE |
| British journal of haematology. 1999 ; 105 (2) : 437-440. |
| PMID 10233417 |
| Identification of heterologous translocation partner genes fused to the BCL6 gene in diffuse large B-cell lymphomas: 5'-RACE and LA - PCR analyses of biopsy samples. |
| Yoshida S, Kaneita Y, Aoki Y, Seto M, Mori S, Moriyama M |
| Oncogene. 1999 ; 18 (56) : 7994-7999. |
| PMID 10637510 |
| Detection of translocations affecting the BCL6 locus in B cell non-Hodgkin's lymphoma by interphase fluorescence in situ hybridization. |
| Sanchez-Izquierdo D, Siebert R, Harder L, Marugan I, Gozzetti A, Price HP, Gesk S, Hernandez-Rivas JM, Benet I, Solˆ© F, Sonoki T, Le Beau MM, Schlegelberger B, Dyer MJ, Garcia-Conde J, Martinez-Climent JA |
| Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 2001 ; 15 (9) : 1475-1484. |
| PMID 11516111 |
| Detection of reciprocal fusion 5'-BCL6/partner-3' transcripts in lymphomas exhibiting reciprocal BCL6 translocations. |
| Kaneita Y, Yoshida S, Ishiguro N, Sawada U, Horie T, Mori S, Moriyama M |
| British journal of haematology. 2001 ; 113 (3) : 803-806. |
| PMID 11380473 |
| Contributor(s) |
| Written | 03-2006 | Jean Loup Huret |
| Citation |
| This paper should be referenced as such : |
| Huret JL . t(3;16)(q27;p13). Atlas Genet Cytogenet Oncol Haematol. March 2006 . URL : http://AtlasGeneticsOncology.org/Anomalies/t0316q27p13ID2089.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Mon May 12 18:12:16 2008 |
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