| Clinics and Pathology |
| Disease | Myelodysplastic syndrome (MDS) and acute myeloid leukaemia (AML) |
| Phenotype / cell stem origin | The AML case was a M6 |
| Epidemiology | Only three cases available; patients (one male, two female patients) were aged 68, 70, and 80 (yrs). |
| Cytogenetics |
| Cytogenetics Morphological | The 3 cases were found using multi-FISH techniques; this translocation may therefore be partially cryptic, especially so as it is found in complex karyotypes. |
| Additional anomalies | Major karyotypic anomalies were present in 3 out of 3 cases; +X and +8 were found in one case. |
| Genes involved and Proteins |
| Note | Genes involved are unknown. |
| External links |
| Other database | t(4;5)(q31;q31) | Mitelman database (CGAP - NCBI) | |
| Other database | t(4;5)(q31;q31) | CancerChromosomes (NCBI) |
| To be noted |
| Additional cases are needed to delineate the epidemiology of this rare entity: you are welcome to submit a paper to our new Case Report section. |
| Bibliography |
| Hidden chromosome abnormalities in haematological malignancies detected by multicolour spectral karyotyping. |
| Veldman T, Vignon C, Schrck E, Rowley JD, Ried T |
| Nature genetics. 1997 ; 15 (4) : 406-410. |
| PMID 9090389 |
| Identification of cytogenetic subclasses and recurring chromosomal aberrations in AML and MDS with complex karyotypes using M-FISH. |
| Van Limbergen H, Poppe B, Michaux L, Herens C, Brown J, Noens L, Berneman Z, De Bock R, De Paepe A, Speleman F |
| Genes, chromosomes & cancer. 2002 ; 33 (1) : 60-72. |
| PMID 11746988 |
| Contributor(s) |
| Written | 02-2008 | Jean-Loup Huret |
| Jean Loup HURET, Genetics, Dept Medical Information, University of Poitiers; CHU Poitiers Hospital, F-86021 Poitiers, France |
| Citation |
| This paper should be referenced as such : |
| Huret JL . t(4;5)(q31;q31). Atlas Genet Cytogenet Oncol Haematol. February 2008 . URL : http://AtlasGeneticsOncology.org/Anomalies/t0405q31q31ID1206.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Mon May 12 18:12:17 2008 |
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