Atlas of Genetics and Cytogenetics in Oncology and Haematology
t(6;11)(q27;q23)
| Identity |
 | |
| t(6;11)(q27;q23) G- banding - Courtesy Diane H. Norback, Eric B. Johnson, Sara Morrison-Delap Cytogenetics at theWaisman Center (top and middle ), and Jean-Luc Lai (below) | |
| Clinics and Pathology |
| Disease | ANLL |
| Phenotype / cell stem origin | M4, M5 mostly; T-cell ALL at times; therapy related AL |
| Epidemiology | still poorly known; found in children and young adults; male predominance |
| Clinics | frequent infections; organomegaly; blood data: moderate WBC |
| Treatment | BMT is indicated |
| Prognosis | very poor (as in other 11q23 rearrangements); rare remission; short survival |
| Cytogenetics |
| Cytogenetics Morphological | may be missinterpreted as a del(11q), as chromosome 6 involvempent may be overlooked |
| Cytogenetics Molecular | ... therefore, FISH may be needed |
| Additional anomalies | are present in most cases; +8 in particular; +3; +19; +21 |
| Genes involved and Proteins |
| Gene Name | AF6 |
| Location | 6q27 |
| Protein | contains a GLGF motif; widely expressed; cytoplasmic localisation; role in signal transduction |
| Gene Name | MLL |
| Location | 11q23 |
| Protein | 431 KDa; contains two DNA binding motifs (a AT hook and Zinc fingers), and a DNA methyl transferase motif; wide expression; nuclear localisation; transcriptional regulatory factor |
| Result of the chromosomal anomaly |
| Description | 5' MLL-3'AF6 |
| Description | about 1400 NH2-term amino acids (with the AT hook and DNA binding motifs) from MLL and most of AF6, starting at amino acid 26 |
| External links |
| Other database | t(6;11)(q27;q23) | Mitelman database (CGAP - NCBI) | |
| Other database | t(6;11)(q27;q23) | CancerChromosomes (NCBI) |
| To be noted |
| having a glance at 11q23 rearrangements, gives an overview of related diseases |
| Bibliography |
| Cloning of the ALL-1 fusion partner, the AF-6 gene, involved in acute myeloid leukemias with the t(6;11) chromosome translocation. |
| Prasad R, Gu Y, Alder H, Nakamura T, Canaani O, Saito H, Huebner K, Gale RP, Nowell PC, Kuriyama K |
| Cancer research. 1993 ; 53 (23) : 5624-5628. |
| PMID 8242616 |
| Unique clinical features and prognostic significance of the translocation (6;11) in acute leukemia. |
| Welborn JL, Jenks HM, Hagemeijer A |
| Cancer genetics and cytogenetics. 1993 ; 65 (2) : 125-129. |
| PMID 8453597 |
| Contributor(s) |
| Written | 11-1997 | Jean-Loup Huret |
| Citation |
| This paper should be referenced as such : |
| Huret JL . t(6;11)(q27;q23). Atlas Genet Cytogenet Oncol Haematol. November 1997 . URL : http://AtlasGeneticsOncology.org/Anomalies/t0611.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Mon May 12 18:12:29 2008 |
For comments and suggestions or contributions, please contact us