Atlas of Genetics and Cytogenetics in Oncology and Haematology
t(7;11)(p15;p15)
| Identity |
 | |
| t(7;11)(p15;p15) G-banding - Courtesy Diane H. Norback, Eric B. Johnson, and Sara Morrison-Delap, UW Cytogenetic Services | |
| Clinics and Pathology |
| Disease | ANLL mostly; occasionally: CML-like cases without t(9;22), or CML in blast crisis (with t(9;22)) |
| Phenotype / cell stem origin | M2 or M4 ANLL mainly; involving maturing leukemic cells in ANLL cases, might affect trilineage progenitors in CML-like cases |
| Epidemiology | most cases have been found in Japan; balanced sex ratio |
| Cytology | auer rods; low alkaline phosphatase scores; CML like blood features |
| Prognosis | CR in most cases; but patients tend to relapse; mean survival: 15 mths |
| Cytogenetics |
| Additional anomalies | most often (90%) none |
| Genes involved and Proteins |
| Gene Name | HOXA9 |
| Location | 7p15 |
| Protein | encodes a class I homeodomain protein potentially involved in myeloid differentiation |
| Gene Name | NUP98 |
| Location | 11p15 |
| Dna / Rna | alternate splicings |
| Protein | contains repeated motifs and a RNA binding motif; nucleoporin: role in nucleo-cytoplasmic transport |
| Result of the chromosomal anomaly |
| Description | 5' NUP98 - 3' HOXA9 |
| Description | fuses the N-term GLFG repeat domains of NUP98 to the HOXA9 3' homeobox |
| Oncogenesis | may promote leukaemogenesis through inhibition of HOXA9-mediated terminal differentiation and/or aberrant nucleocytoplasmic transport |
| External links |
| Other database | t(7;11)(p15;p15) | Mitelman database (CGAP - NCBI) | |
| Other database | t(7;11)(p15;p15) | CancerChromosomes (NCBI) |
| Bibliography |
| Reciprocal translocation involving the short arms of chromosomes 7 and 11, t(7p-;11p+), associated with myeloid leukemia with maturation. |
| Sato Y, Abe S, Mise K, Sasaki M, Kamada N, Kouda K, Musashi M, Saburi Y, Horikoshi A, Minami Y |
| Blood. 1987 ; 70 (5) : 1654-1658. |
| PMID 3478104 |
| Two additional cases of acute myeloid leukemia with t(7;11)(p15;p15) having low neutrophil alkaline phosphatase scores. |
| Fujimura T, Ohyashiki K, Ohyashiki JH, Kawakubo K, Iwabuchi A, Kodama A, Toyama K |
| Cancer genetics and cytogenetics. 1993 ; 68 (2) : 143-146. |
| PMID 8353806 |
| The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9. |
| Borrow J, Shearman AM, Stanton VP Jr, Becher R, Collins T, Williams AJ, Dubˆ© I, Katz F, Kwong YL, Morris C, Ohyashiki K, Toyama K, Rowley J, Housman DE |
| Nature genetics. 1996 ; 12 (2) : 159-167. |
| PMID 8563754 |
| Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia. |
| Nakamura T, Largaespada DA, Lee MP, Johnson LA, Ohyashiki K, Toyama K, Chen SJ, Willman CL, Chen IM, Feinberg AP, Jenkins NA, Copeland NG, Shaughnessy JD Jr |
| Nature genetics. 1996 ; 12 (2) : 154-158. |
| PMID 8563753 |
| Contributor(s) |
| Written | 01-1999 | Jean-Loup Huret |
| Citation |
| This paper should be referenced as such : |
| Huret JL . t(7;11)(p15;p15). Atlas Genet Cytogenet Oncol Haematol. January 1999 . URL : http://AtlasGeneticsOncology.org/Genes/t0711p15.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Wed Sep 24 21:06:55 2008 |
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