| Identity |
| Note | This data is extracted from a very large study from an International Workshop on treatment related leukemias - restricted to balanced chromosome aberrations (i.e.: -5/del(5q)and -7/del(7q) not taken into account per see), published in Genes,Chromosomes and Cancer in 2002. |
| Clinics and Pathology |
| Disease | Treatment related myelodysplasia (t-MDS) or acute non lymphocytic leukaemias (t-ANLL) |
| Note | The study included 44 cases; t-MDS with or without progression to ANLL accounted for 20% and t-ANLL for the remaining 80%; no case of acute lymphoblastic leukaemia |
| Epidemiology | t(8;21)(q22;q22) was found in 9% of t-MDS/t-ANLL; 1M to 1F sex ratio |
| Clinics | Age at diagnosis of the primary disease 45 yrs (range 2-75); age at diagnosis of the t-MDS/t-ANLL: 47 yrs for patients with the t(8;21) solely and 50 yrs for patients with an additional anomaly; range was(15-77). Median interval was 39 mths for cases with t(8;21) solely, and 33 mths in other cases; (range: 6-306). Primary disease was a solid tumor in 70% of cases ( breast cancer in particular) and a hematologic malignancy in 30%, treated with radiotherapy (12%), chemotherapy (42%), or both (46%). |
| Cytology | Cell morphology was similar to those of de novo t(8;21) |
| Prognosis | Median survival was 17mths and 31 mths respectively for patients without and with additionnal anomalies, but the difference was not significant. Outcome was better than the outcome of patients with 11q23 rearrangement, 3q21q26 rearrangement, 12p13 rearrangement, t(9;22), t(8;16), or a t(3;21) and worse than the outcome of patients with with t(15;17) or inv(16) treatment related leukemias. |
| Cytogenetics |
| Additional anomalies | The t(8;21) was found solely in 25% of cases; additional anomalies were: -Y or -X in 25% of cases, del(9q) in 18 %, +8 in 9%, -7/del(7q) in 7%. A complex karyotype was found in 32% of cases |
| Result of the chromosomal anomaly |
| Description | 5' AML1 - 3' ETO; breakpoint is most often in the AML1 intron 5. |
| External links |
| Other database | t(8;21)(q22;q22) in treatment related leukemia | Mitelman database (CGAP - NCBI) | |
| Other database | t(8;21)(q22;q22) in treatment related leukemia | CancerChromosomes (NCBI) |
| Bibliography |
| 21q22 balanced chromosome aberrations in therapy-related hematopoietic disorders: report from an international workshop. |
| Slovak ML, Bedell V, Popplewell L, Arber DA, Schoch C, Slater R |
| Genes, chromosomes & cancer. 2002 ; 33 (4) : 379-394. |
| PMID 11921272 |
| Contributor(s) |
| Written | 10-2003 | Jean-Loup Huret |
| Citation |
| This paper should be referenced as such : |
| Huret JL . t(8;21)(q22;q22) in treatment related leukemia. Atlas Genet Cytogenet Oncol Haematol. October 2003 . URL : http://AtlasGeneticsOncology.org/Anomalies/t0821q22q22TreatRelID1293.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Mon May 12 18:12:42 2008 |
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