Atlas of Genetics and Cytogenetics in Oncology and Haematology
t(9;11)(q34;p15)
| Clinics and Pathology |
| Disease | Acute myelomonocytic leukemia (M4 ANLL) |
| Etiology | this leukemia case is likely to be treatment related (a lymphoma was treated 4 yrs previously) |
| Epidemiology | only one case to date: a 65 yr old female patient |
| Prognosis | no data |
| Genes involved and Proteins |
| Gene Name | PRRX2 |
| Location | 9q34 |
| Protein | class II homeobox gene |
| Gene Name | NUP98 |
| Location | 11p15.4 |
| Protein | nucleoporin 98, a 98 kDa component of the nuclear pore complex implicated in nucleo-cytoplasmic transport |
| Result of the chromosomal anomaly |
 | |
| Description | 5'--> exon 11 of NUP98 is fused in frame with PRRX2 exon 2 to 3' |
| External links |
| Other database | t(9;11)(q34;p15) | Mitelman database (CGAP - NCBI) | |
| Other database | t(9;11)(q34;p15) | CancerChromosomes (NCBI) |
| To be noted |
| Additional cases are needed to delineate the epidemiology of this rare entity: you are welcome to submit a paper to our new Case Report section. |
| Bibliography |
| A new translocation t(9;11)(q34;p15) fuses NUP98 to a novel homeobox partner gene, PRRX2, in a therapy-related acute myeloid leukemia. |
| Gervais C, Mauvieux L, Perrusson N, Hˆ©lias C, Struski S, Leymarie V, Lioure B, Lessard M |
| Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 2005 ; 19 (1) : 145-148. |
| PMID 15496970 |
| Contributor(s) |
| Written | 01-2005 | Jean loup Huret |
| Citation |
| This paper should be referenced as such : |
| Huret JL . t(9;11)(q34;p15). Atlas Genet Cytogenet Oncol Haematol. January 2005 . URL : http://AtlasGeneticsOncology.org/Anomalies/t0911q34p15ID1380.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Mon May 12 18:12:45 2008 |
For comments and suggestions or contributions, please contact us