| Identity |
| Note | This data is extracted from a very large study from an International Workshop on treatment related leukemias - restricted to balanced chromosome aberrations (i.e.: -5/del(5q)and -7/del(7q) not taken into account per see), published in Genes,Chromosomes and Cancer in 2002. |
| Clinics and Pathology |
| Disease | Treatment related acute non lymphocytic leukaemias (t-ANLL) and lymphocytic leukemias (t-ALL) |
| Note | The study included 10 cases; t-ANLL and t-ALL accounted for half cases each. Treatment related acute lymphocytic leukemias (t-ALL) are extremely rare, found in only 20 of 511 cases (4%) in this workshop: 5 cases of t(9;22), 12 cases of t(4;11)(q22;q23), 2 cases of t(8;14)(q24;q32), and 1 case of t(11;19)(q23;p13.3) |
| Epidemiology | t(9;22)(q34;q11) was found in 2% of treatment related acute leukaemias; sex ratio: 2M/8F |
| Clinics | Age at diagnosis of the primary disease 45 yrs (range 3-76); age at diagnosis of the t-MDS/t-ANLL: 64 yrs (range 12-78). Median interval was long: 110 mths (range: 25-310). Primary disease was a solid tumor in 70% of cases (in particular breast cancer) and a hematologic malignancy in 20%; treatment was radiotherapy in 1/10, chemotherapy (6/10), or both (3/10). Treatment included topoisomerase II inhibitors in 4 of 9 cases and alkylating agents in 5/9. |
| Prognosis | Median survival was very poor: 5 mths, with 14% of patients surviving at 1 yr, and none at 2 yrs. |
| Cytogenetics |
| Additional anomalies | Complex karyotypes were found in 6 of 10 cass. |
| Result of the chromosomal anomaly |
| Description | 5' BCR -3¹ ABL |
| External links |
| Other database | t(9;22)(q34;q11) in treatment related leukemia | Mitelman database (CGAP - NCBI) | |
| Other database | t(9;22)(q34;q11) in treatment related leukemia | CancerChromosomes (NCBI) |
| Bibliography |
| Rare recurring balanced chromosome abnormalities in therapy-related myelodysplastic syndromes and acute leukemia: report from an international workshop. |
| Block AW, Carroll AJ, Hagemeijer A, Michaux L, van Lom K, Olney HJ, Baer MR |
| Genes, chromosomes & cancer. 2002 ; 33 (4) : 401-412. |
| PMID 11921274 |
| Contributor(s) |
| Written | 10-2003 | Jean-Loup Huret |
| Citation |
| This paper should be referenced as such : |
| Huret JL . t(9;22)(q34;q11) in treatment related leukemia. Atlas Genet Cytogenet Oncol Haematol. October 2003 . URL : http://AtlasGeneticsOncology.org/Anomalies/t0922q34q11TreatRelID1300.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Mon May 12 18:12:50 2008 |
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