| Clinics and Pathology |
| Disease | T-cell ALL |
| Genes involved and Proteins |
| Gene Name | TAL1 |
| Location | 1p32 |
| Dna / Rna | complex alternate splicing |
| Protein | contains a basic Helix-Loop-Helix (DNA binding) domain; cforms heterodimers; transcription factor; role in haematopoietic cell differentiation |
| Gene Name | TCTA |
| Location | 3p21 |
| Protein | contains a hydrophobic domain; may be a membrane associated protein |
| Result of the chromosomal anomaly |
| Description | TCTA and TAL1 are in opposite direction |
| Description | it may be that the promoting regions from TCTA disregulate TAL1 expression |
| External links |
| Other database | t(1;3)(p32;p21) | Mitelman database (CGAP - NCBI) | |
| Other database | t(1;3)(p32;p21) | CancerChromosomes (NCBI) |
| Bibliography |
| Disruption of the SCL gene by a t(1;3) translocation in a patient with T cell acute lymphoblastic leukemia. |
| Aplan PD, Raimondi SC, Kirsch IR |
| The Journal of experimental medicine. 1992 ; 176 (5) : 1303-1310. |
| PMID 1402676 |
| Cloning and characterization of TCTA, a gene located at the site of a t(1;3) translocation. |
| Aplan PD, Johnson BE, Russell E, Chervinsky DS, Kirsch IR |
| Cancer research. 1995 ; 55 (9) : 1917-1921. |
| PMID 7728759 |
| Contributor(s) |
| Written | 03-1998 | Jean-Loup Huret |
| Citation |
| This paper should be referenced as such : |
| Huret JL . t(1;3)(p32;p21). Atlas Genet Cytogenet Oncol Haematol. March 1998 . URL : http://AtlasGeneticsOncology.org/Anomalies/t1031108.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Mon May 12 18:12:55 2008 |
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