Atlas of Genetics and Cytogenetics in Oncology and Haematology
t(11;15)(q23;q14)
| Identity |
 | |
| t(11;15)(q23;q14) (R-banding) - Christiane Charrin. | |
| Clinics and Pathology |
| Disease | only 1 case with the ascertainment of AF15q14 involvement; a the very few other cases may or may not carry the same rearrangement |
| Phenotype / cell stem origin | M4 ANLL in the AF15q14 case |
| Clinics | a 48 yr old man with previous history of toxic exposure who died 4 mths after diagnosis |
| Cytogenetics |
| Additional anomalies | + mar |
| Genes involved and Proteins |
| Gene Name | MLL |
| Location | 11q23 |
| Dna / Rna | 21 exons, spanning over 100 kb; 13-15 kb mRNA |
| Protein | 3969 amino acids; 431 KDa; contains two DNA binding motifs: a AT hook homologous to high mobility group proteins HMGI-(Y) and HMGI(C) that binds to the minor groove of DNA , and zinc fingers, a DNA methyl transferase motif, a bromodomain, and segments of homology with trithorax, in particular in the C-terminal SET domain |
| Gene Name | AF15q14 |
| Location | 15q14 |
| Dna / Rna | at least 10 exons; spans more than 35 kb |
| Protein | 1833 amino acids; 206 kDa; nuclear localization domain in the c-term |
| External links |
| Other database | t(11;15)(q23;q14) | Mitelman database (CGAP - NCBI) | |
| Other database | t(11;15)(q23;q14) | CancerChromosomes (NCBI) |
| To be noted |
| Additional cases are needed to delineate the epidemiology of this rare entity: you are welcome to submit a paper to our new Case Report section. |
| Bibliography |
| Frequency and prognostic significance of HRX rearrangements in infant acute lymphoblastic leukemia: a Pediatric Oncology Group study. |
| Rubnitz JE, Link MP, Shuster JJ, Carroll AJ, Hakami N, Frankel LS, Pullen DJ, Cleary ML |
| Blood. 1994 ; 84 (2) : 570-573. |
| PMID 8025282 |
| Translocation (11;15)(q23;q14) in three patients with acute non-lymphoblastic leukemia (ANLL): clinical, cytogenetic and molecular studies. |
| Hernˆ°ndez JM, Mecucci C, Beverloo HB, Selleri L, Wlodarska I, Stul M, Michaux L, Verhoef G, Van Orshoven A, Cassiman JJ |
| Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 1995 ; 9 (7) : 1162-1166. |
| PMID 7630191 |
| AF15q14, a novel partner gene fused to the MLL gene in an acute myeloid leukaemia with a t(11;15)(q23;q14). |
| Hayette S, Tigaud I, Vanier A, Martel S, Corbo L, Charrin C, Beillard E, Deleage G, Magaud JP, Rimokh R |
| Oncogene. 2000 ; 19 (38) : 4446-4450. |
| PMID 10980622 |
| Contributor(s) |
| Written | 03-2000 | Jean-Loup Huret, Christiane Charrin |
| Citation |
| This paper should be referenced as such : |
| Huret JL, Charrin C . t(11;15)(q23;q14). Atlas Genet Cytogenet Oncol Haematol. March 2000 . URL : http://AtlasGeneticsOncology.org/Anomalies/t1115ID1199.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Mon May 12 18:12:59 2008 |
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