Atlas of Genetics and Cytogenetics in Oncology and Haematology
t(11;17)(q23;q25)
| Identity |
 | |
| t(11;17)(q23;q25) G-banding - Courtesy Jean Luc Lai | |
| Clinics and Pathology |
| Disease | de novo and treatment related acute non lymphocytic leukemia (ANLL), myelodysplastic syndromes (MDS); acute lymphoblastic leukemia (ALL) at times |
| Phenotype / cell stem origin | various subtypes of ANLL may be found, M4 in particular, but also M1, M2, M5 |
| Epidemiology | at least 24 cases described; often found in children and young adults |
| Prognosis | poor |
| Genes involved and Proteins |
| Gene Name | MLL |
| Location | 11q23 |
| Protein | contains two DNA binding motifs (a AT hook, and Zinc fingers), a DNA methyl transferase motif, a bromodomain; transcriptional regulatory factor; nuclear localisation |
| Gene Name | MSF |
| Location | 17q25 |
| Protein | protein which belongs to the septin family |
| Result of the chromosomal anomaly |
| Description | 5' MLL - 3' MSF; fusion at MLL exon 5; the reciprocal MSF-MLL is also transcribed, but out of frame |
| Description | NH2 - AT hook and DNA methyltransferase from MLL fused to most of MSF in COOH |
| External links |
| Other database | t(11;17)(q23;q25) | Mitelman database (CGAP - NCBI) | |
| Other database | t(11;17)(q23;q25) | CancerChromosomes (NCBI) |
| Bibliography |
| Ten novel 11q23 chromosomal partner sites. European 11q23 Workshop participants. |
| Harrison CJ, Cuneo A, Clark R, Johansson B, Lafage-Pochitaloff M, Mugneret F, Moorman AV, Secker-Walker LM |
| Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 1998 ; 12 (5) : 811-822. |
| PMID 9593286 |
| MSF (MLL septin-like fusion), a fusion partner gene of MLL, in a therapy-related acute myeloid leukemia with a t(11;17)(q23;q25). |
| Osaka M, Rowley JD, Zeleznik-Le NJ |
| Proceedings of the National Academy of Sciences of the United States of America. 1999 ; 96 (11) : 6428-6433. |
| PMID 10339604 |
| AF17q25, a putative septin family gene, fuses the MLL gene in acute myeloid leukemia with t(11;17)(q23;q25). |
| Taki T, Ohnishi H, Shinohara K, Sako M, Bessho F, Yanagisawa M, Hayashi Y |
| Cancer research. 1999 ; 59 (17) : 4261-4265. |
| PMID 10485469 |
| Contributor(s) |
| Written | 04-2000 | Jean-Loup Huret |
| Citation |
| This paper should be referenced as such : |
| Huret JL . t(11;17)(q23;q25). Atlas Genet Cytogenet Oncol Haematol. April 2000 . URL : http://AtlasGeneticsOncology.org/Genes/t1117ID1133.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Wed Sep 24 21:07:22 2008 |
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