Atlas of Genetics and Cytogenetics in Oncology and Haematology
t(1;11)(q21;q23)
| Identity |
 | |
| t(1;11)(q21;q23) G- banding: - Courtesy Charles D. Bangs | |
| Clinics and Pathology |
| Disease | ANLL, ALL at times |
| Phenotype / cell stem origin | 30 cases were reported. 25 of them were ANLL: mostly M4/M5 (16), 2 M1, 1 M2, 3 secondary (s) LAM, in 3 cases FAB type were not described. The other cases were : 2 ALL, 1 biphenotypic ALL, 1 sALL and 1 sMSD. |
| Epidemiology | most cases were infants (10/23) and children (7/23) , range is 4 months - 62 years, balanced sex ratio (14F/12M on 26 cases). |
| Prognosis | Yet unknown |
| Cytogenetics |
| Cytogenetics Morphological | presents as der(11)t(1;11)(q21;q23) in 9 of the 30 cases. Unbalanced form is identified in the 4 ALL and in all of the secondary cases. |
| Additional anomalies | balanced translocation is present as sole anomaly in 16/21 cases, and as part of simple karyotype in 5/21 cases ;+ 19, +22 were recurrent. Additional abnormalities were observed in 8 of the 9 cases showing the der (11); karyotype of 5 cases were highly complex. |
| Variants | two three-way translocations were identified : t(1;11;3)(q21;q23;q21) and t(1;11;4)(q21;q23;p16). |
| Genes involved and Proteins |
| Gene Name | AF1q |
| Location | 1q21 |
| Dna / Rna | 1.8 kb mRNA |
| Protein | 9 kDa |
| Gene Name | MLL |
| Location | 11q23 |
| Dna / Rna | 21 exons, spanning over 100 kb; 13-15 kb mRNA |
| Protein | 431 kDa; contains two DNA binding motifs (a AT hook, and Zinc fingers), a DNA methyl transferase motif, a bromodomain; transcriptional regulatory factor; nuclear localisation transcriptional regulatory factor; nuclear localisation |
| Result of the chromosomal anomaly |
| Description | 5' MLL-3' AF1q; breakpoints: between exons 6 and 7 in MLL and within the 5' untranslated region in AF1q |
| Description | N-term -- AT hook (DNA binding) and DNA methyltransferase motif from MLL fused to the entire AF1q on the der(11); the reciprocal on der(1) is out of frame. |
| External links |
| Other database | t(1;11)(q21;q23) | Mitelman database (CGAP - NCBI) | |
| Other database | t(1;11)(q21;q23) | CancerChromosomes (NCBI) |
| Bibliography |
| Translocation t(1;11)(q21;q23), a new subgroup within M4 acute nonlymphocytic leukemia. |
| Meloni-Balliet AM, Morgan R, Piatt J, Sandberg AA |
| Cancer genetics and cytogenetics. 1989 ; 37 (2) : 269-271. |
| PMID 2702626 |
| A novel gene, AF1q, fused to MLL in t(1;11) (q21;q23), is specifically expressed in leukemic and immature hematopoietic cells. |
| Tse W, Zhu W, Chen HS, Cohen A |
| Blood. 1995 ; 85 (3) : 650-656. |
| PMID 7833468 |
| Ten novel 11q23 chromosomal partner sites. European 11q23 Workshop participants. |
| Harrison CJ, Cuneo A, Clark R, Johansson B, Lafage-Pochitaloff M, Mugneret F, Moorman AV, Secker-Walker LM |
| Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 1998 ; 12 (5) : 811-822. |
| PMID 9593286 |
| MLL-AF1q fusion resulting from t(1;11) in acute leukemia. |
| Busson-Le Coniat M, Salomon-Nguyen F, Hillion J, Bernard OA, Berger R |
| Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 1999 ; 13 (2) : 302-306. |
| PMID 10025907 |
| Analysis of MLL-derived transcripts in infant acute monocytic leukemia with a complex translocation (1;11;4)(q21;q23;p16). |
| So CW, Ma SK, Wan TS, Chan GC, Ha SY, Chan LC |
| Cancer genetics and cytogenetics. 2000 ; 117 (1) : 24-27. |
| PMID 10700861 |
| Analysis of MLL-derived transcripts in infant acute monocytic leukemia with a complex translocation (1;11;4)(q21;q23;p16). |
| So CW, Ma SK, Wan TS, Chan GC, Ha SY, Chan LC |
| Cancer genetics and cytogenetics. 2000 ; 117 (1) : 24-27. |
| PMID 10700861 |
| Contributor(s) |
| Written | 04-1998 | Jean-Loup Huret |
| Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France |
| Citation |
| This paper should be referenced as such : |
| Huret JL . t(1;11)(q21;q23). Atlas Genet Cytogenet Oncol Haematol. April 1998 . URL : http://AtlasGeneticsOncology.org/Anomalies/t111ID1004.html |
| Collonge-Rame MA . t(1;11)(q21;q23). Atlas Genet Cytogenet Oncol Haematol. . URL : http://AtlasGeneticsOncology.org/Anomalies/t111ID1004.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Mon May 12 18:13:03 2008 |
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