| Clinics and Pathology |
| Disease | the translocation is cytogenetically detectable in a minority of extranodal MALT lymphomas; irrespective of the presence of the 1;14 translocation, mutation or deletion of the BCL10 gene located at 1p22 can be detected by molecular genetic methods in 5-10% of extra-nodal MALT lymphomas, follicle centre cell lymphoma and diffuse large B-cell lymphoma; among MALT lymphoma a preferential association was noted with high-grade histology |
| Prognosis | in MALT lymphoma there may be an association with aggressive histology and antibiotic-unresponsive forms |
| Cytogenetics |
| Cytogenetics Morphological | the translocation is readily detectable by conventional karyotyping |
| Genes involved and Proteins |
| Note | the breakpoints on chromosome 1p22 are located upstream of the promoter of the BCL10 gene, which shows inactivating mutations or deletions |
| Gene Name | BCL10 |
| Location | 1p22 |
| Protein | 322 amino acids; contains a caspase recruitment domain; role in the apoptosis |
| Gene Name | IgH |
| Location | 14q32 |
| External links |
| Other database | t(1;14)(p22;q32) in non Hodgkin's lymphoma (NHL) | Mitelman database (CGAP - NCBI) | |
| Other database | t(1;14)(p22;q32) in non Hodgkin's lymphoma (NHL) | CancerChromosomes (NCBI) |
| Bibliography |
| Cytogenetic study of B-cell lymphoma of mucosa-associated lymphoid tissue. |
| Wotherspoon AC, Pan LX, Diss TC, Isaacson PG |
| Cancer genetics and cytogenetics. 1992 ; 58 (1) : 35-38. |
| PMID 1728948 |
| Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types. |
| Willis TG, Jadayel DM, Du MQ, Peng H, Perry AR, Abdul-Rauf M, Price H, Karran L, Majekodunmi O, Wlodarska I, Pan L, Crook T, Hamoudi R, Isaacson PG, Dyer MJ |
| Cell. 1999 ; 96 (1) : 35-45. |
| PMID 9989495 |
| Inactivating mutations and overexpression of BCL10, a caspase recruitment domain-containing gene, in MALT lymphoma with t(1;14)(p22;q32). |
| Zhang Q, Siebert R, Yan M, Hinzmann B, Cui X, Xue L, Rakestraw KM, Naeve CW, Beckmann G, Weisenburger DD, Sanger WG, Nowotny H, Vesely M, Callet-Bauchu E, Salles G, Dixit VM, Rosenthal A, Schlegelberger B, Morris SW |
| Nature genetics. 1999 ; 22 (1) : 63-68. |
| PMID 10319863 |
| BCL10 gene mutation in lymphoma. |
| Du MQ, Peng H, Liu H, Hamoudi RA, Diss TC, Willis TG, Ye H, Dogan A, Wotherspoon AC, Dyer MJ, Isaacson PG |
| Blood. 2000 ; 95 (12) : 3885-3890. |
| PMID 10845924 |
| Contributor(s) |
| Written | 01-2001 | Antonio Cuneo, Gianluigi Castoldi |
| Citation |
| This paper should be referenced as such : |
| Cuneo A and Castoldi GL . t(1;14)(p22;q32) in non Hodgkin's lymphoma (NHL). Atlas Genet Cytogenet Oncol Haematol. January 2001 . URL : http://AtlasGeneticsOncology.org/Genes/t114ID2044.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Wed Sep 24 21:07:26 2008 |
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