Atlas of Genetics and Cytogenetics in Oncology and Haematology
t(15;17)(q22;q21) in treatment related leukemia
| Identity |
| Note | This data is extracted from a very large study from an International Workshop on treatment related leukemias - restricted to balanced chromosome aberrations (i.e.: -5/del(5q)and -7/del(7q) not taken into account per see), published in Genes,Chromosomes and Cancer in 2002. |
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| t(15;17)(q22;q21) G-banding - Courtesy Diane H. Norback, Eric B. Johnson, and Sara Morrison-Delap, UW Cytogenetic Services | |
| Clinics and Pathology |
| Disease | Treatment related myelodysplasia (t-MDS) or acute non lymphocytic leukaemias (t-ANLL) |
| Note | The study included 41 cases; t-MDS with progression to ANLL accounted for 7% and t-ANLL for the remaining 93% the ANLL subtype was M3 in all but one case; no case of acute lymphoblastic leukaemia |
| Epidemiology | t(15;17)(q22;q21) was found in 8% of t-MDS/t-ANLL; sex ratio: 15M/26F |
| Clinics | Age at diagnosis of the primary disease 46 yrs (range 18-79); age at diagnosis of the t-MDS/t-ANLL: 49 yrs (range 19-81). Median interval was 29 mths (range: 9-175). Primary disease was a solid tumor in 71% of cases ( breast cancer in particular) and a hematologic malignancy in 27%, treatment was radiotherapy (29%, a high proportion compared to other groups), chemotherapy (17%), or both (54%). Treatment included topoisomerase II inhibitors in 49% of cases and alkylating agents in 59%. |
| Prognosis | Median survival was 29 mths. Outcome was better than the outcome of patients with 11q23 rearrangement, 3q21q26 rearrangement, 12p13 rearrangement, t(9;22), t(8;16), or a 21q22 rearangement) and similar, during the first 2 yrs to that of the inv(16) treatment related leukemias. |
| Cytogenetics |
| Additional anomalies | The t(15;17) was found solely in 59% of cases; additional anomalies were: +8 in 12% , -5/del(5q) in 5%, or -7/del(7q). |
| Result of the chromosomal anomaly |
| Description | 5¹ PML -3¹ RARA |
| External links |
| Other database | t(15;17)(q22;q21) in treatment related leukemia | Mitelman database (CGAP - NCBI) | |
| Other database | t(15;17)(q22;q21) in treatment related leukemia | CancerChromosomes (NCBI) |
| Bibliography |
| Balanced chromosome abnormalities inv(16) and t(15;17) in therapy-related myelodysplastic syndromes and acute leukemia: report from an international workshop. |
| Andersen MK, Larson RA, Mauritzson N, Schnittger S, Jhanwar SC, Pedersen-Bjergaard J |
| Genes, chromosomes & cancer. 2002 ; 33 (4) : 395-400. |
| PMID 11921273 |
| Contributor(s) |
| Written | 10-2003 | Jean-Loup Huret |
| Citation |
| This paper should be referenced as such : |
| Huret JL . t(15;17)(q22;q21) in treatment related leukemia. Atlas Genet Cytogenet Oncol Haematol. October 2003 . URL : http://AtlasGeneticsOncology.org/Anomalies/t1517q22q21TreatRelID1298.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Mon May 12 18:13:14 2008 |
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