MLLT6 (myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6)

Identity

Other names	AF17 (ALL1 fused gene from chromosome 17)
HGNC	MLLT6
Location	17q21
Location_base_pair	Starts at 34115399 and ends at 34139582 bp from pter ( according to hg18-Mar_2006).
Local_order	proximal to RARA, also in 17q21; HLF is even more distal in 17q22

DNA/RNA

Transcription

7.5 and 5 kb mRNA; coding sequence: 3.3 kb

Protein

Description	1093 amino acids; N- term - 3 Zn fingers (LAP type) and a leucine zipper - C-term; a leucine zipper is a dimerization motif
Localisation	nuclear
Function	transcriptional regulation factor
Homology	with AF10 and BR140, a gene sitting in 3p25

Implicated in

Entity	t(11;17)(q23;q21) /ANLL --> MLL-AF17
Disease	ANLL and MDS
Cytogenetics	additional anomaly: +8
Hybrid/Mutated Gene	5' MLL - 3' AF17
Abnormal Protein	N-term AT hook and DNA methyltransferase from MLL fused to the leucine zipper C-term of AF17

External links

	Nomenclature
HGNC	MLLT6   7138
Entrez_Gene	MLLT6  4302  myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
	Cards
Atlas	AF17
GeneCards	MLLT6
Ensembl	ENSG00000108292 [Gene_View]  MLLT6 [Vega]
Genatlas	MLLT6
	Genomic and cartography
GoldenPath	MLLT6  -  17q21   chr17:34115399-34139582 +  17q21   [Description]    (hg18-Mar_2006)
Ensembl	MLLT6 - 17q21 [CytoView]
NCBI	Mapview
OMIM	600328 Disease map [OMIM]
HomoloGene	MLLT6
	Gene and transcription
Genbank	AB209633 [ ENTREZ ]
Genbank	AF075118 [ ENTREZ ]
Genbank	AK027133 [ ENTREZ ]
Genbank	AK057058 [ ENTREZ ]
Genbank	AK092893 [ ENTREZ ]
RefSeq	NM_005937 [ SRS ]    NM_005937 [ ENTREZ ]
RefSeq	AC_000060 [ SRS ]    AC_000060 [ ENTREZ ]
RefSeq	AC_000149 [ SRS ]    AC_000149 [ ENTREZ ]
RefSeq	NC_000017 [ SRS ]    NC_000017 [ ENTREZ ]
RefSeq	NT_010755 [ SRS ]    NT_010755 [ ENTREZ ]
RefSeq	NW_001838435 [ SRS ]    NW_001838435 [ ENTREZ ]
RefSeq	NW_926828 [ SRS ]    NW_926828 [ ENTREZ ]
CCDS	MLLT6 CCDS - NCBI
AceView	MLLT6 AceView - NCBI
Unigene	Hs.605712 [ SRS ]    Hs.605712 [ NCBI ]
Fast-db	9323 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P55198 [ SRS]    P55198 [ EXPASY ]     P55198 [ INTERPRO ]     P55198 [ UNIPROT ] P55198 [ VarSplice FASTA ]
Prosite	PS01359 ZF_PHD_1 [ SRS ]    PS01359 ZF_PHD_1 [ Expasy ]
Prosite	PS50016 ZF_PHD_2 [ SRS ]    PS50016 ZF_PHD_2 [ Expasy ]
Interpro	IPR001965 Znf_PHD [ SRS ]    IPR001965 Znf_PHD [ EBI ]
CluSTr	P55198
Pfam	PF00628 PHD [ SRS ]    PF00628 PHD [ Sanger ]    pfam00628 [ NCBI-CDD ]
Smart	SM00249 PHD [EMBL]
Blocks	P55198
HPRD	08978
	Protein Interaction databases
DIP	P55198
IntAct	P55198
	Polymorphism : SNP, mutations, diseases
OMIM	600328    [ map ]
GENETests	600328
SNP	MLLT6 [dbSNP-NCBI]
SNP	NM_005937 [SNP-NCI]
SNP	MLLT6 [GeneSNPs - Utah]  MLLT6] [HGBASE - SRS]
HAPMAP	MLLT6 [HAPMAP]
COSMIC	MLLT6 [Somatic mutation (COSMIC-CGP-Sanger)]
TICdb	MLLT6 [Translocation breakpoints In Cancer]
HGMD	MLLT6
Genetic Association	MLLT6
CDC HuGE	MLLT6
	General knowledge
Family Browser	MLLT6 [UCSC Family Browser]
SOURCE	NM_005937
SMD	Hs.605712
SAGE	Hs.605712
GO	protein binding [Amigo]  protein binding
GO	protein binding [Amigo]  protein binding
GO	nucleus [Amigo]  nucleus
GO	regulation of transcription, DNA-dependent [Amigo]  regulation of transcription, DNA-dependent
GO	zinc ion binding [Amigo]  zinc ion binding
GO	metal ion binding [Amigo]  metal ion binding
PubGene	MLLT6
TreeFam	MLLT6
CTD	4302 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	MLLT6 Related clones (RZPD - Berlin)
	PubMed
PubMed	6 Pubmed reference(s) in Entrez

Bibliography

Leucine-zipper dimerization motif encoded by the AF17 gene fused to ALL-1 (MLL) in acute leukemia.

Prasad R, Leshkowitz D, Gu Y, Alder H, Nakamura T, Saito H, Huebner K, Berger R, Croce CM, Canaani E

Proceedings of the National Academy of Sciences of the United States of America. 1994 ; 91 (17) : 8107-8111.

PMID 8058765

Chromosome abnormalities in leukaemia: the 11q23 paradigm.

Young BD, Saha V

Cancer surveys. 1996 ; 28 : 225-245.

PMID 8977038

Molecular basis of 11q23 rearrangements in hematopoietic malignant proliferations.

Bernard OA, Berger R

Genes, chromosomes & cancer. 1995 ; 13 (2) : 75-85.

PMID 7542910

11q23 rearrangements in acute leukemia.

Rubnitz JE, Behm FG, Downing JR

Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 1996 ; 10 (1) : 74-82.

PMID 8558942

REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	12-1997	Jean-Loup Huret

Citation

This paper should be referenced as such :

Huret JL . MLLT6 (myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6). Atlas Genet Cytogenet Oncol Haematol. December 1997 . URL : http://AtlasGeneticsOncology.org/Genes/AF17.html

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Thu Nov 27 13:18:57 2008