| Nomenclature | | HGNC | EPS15 3419 |
| Entrez_Gene | EPS15 2060 epidermal growth factor receptor pathway substrate 15 |
| Cards |
|---|
| Atlas | AF1pID11 |
| GeneCards | EPS15 |
| Ensembl | EPS15 [Search_View] ENSG00000085832 [Gene_View] |
| Genatlas | EPS15 |
| GeneLynx | EPS15 |
| eGenome | EPS15 |
| euGene | 2060 |
| Genomic and cartography |
|---|
| GoldenPath | EPS15 - 1p32 chr1:51592523-51757583 - 1p32 [Description] (hg18-Mar_2006) |
| Ensembl | EPS15 - 1p32 [CytoView] |
| NCBI | Mapview |
| OMIM | Disease map [OMIM] |
| HomoloGene | EPS15 |
| Gene and transcription | | Genbank | AF052132 [ ENTREZ ] |
| Genbank | AK090936 [ ENTREZ ] |
| Genbank | AK129853 [ ENTREZ ] |
| Genbank | AK308128 [ ENTREZ ] |
| Genbank | AK313396 [ ENTREZ ] |
| RefSeq | NM_001981 [ SRS ] NM_001981 [ ENTREZ ] |
| RefSeq | AC_000044 [ SRS ] AC_000044 [ ENTREZ ] |
| RefSeq | AC_000133 [ SRS ] AC_000133 [ ENTREZ ] |
| RefSeq | NC_000001 [ SRS ] NC_000001 [ ENTREZ ] |
| RefSeq | NT_032977 [ SRS ] NT_032977 [ ENTREZ ] |
| RefSeq | NW_001838579 [ SRS ] NW_001838579 [ ENTREZ ] |
| RefSeq | NW_921351 [ SRS ] NW_921351 [ ENTREZ ] |
| AceView | EPS15 AceView - NCBI |
| Unigene | Hs.83722 [ SRS ] Hs.83722 [ NCBI ]
HS83722 [ spliceNest ] |
| Fast-db | 15994 (alternative variants) |
| Protein : pattern, domain, 3D structure |
|---|
| SwissProt | P42566 [ SRS] P42566 [ EXPASY ] P42566 [ INTERPRO ] P42566 [ UNIPROT ] |
| Prosite | PS00018 EF_HAND_1 [ SRS ] PS00018 EF_HAND_1 [ Expasy ] |
| Prosite | PS50222 EF_HAND_2 [ SRS ] PS50222 EF_HAND_2 [ Expasy ] |
| Prosite | PS50031 EH [ SRS ] PS50031 EH [ Expasy ] |
| Prosite | PS50330 UIM [ SRS ] PS50330 UIM [ Expasy ] |
| Interpro | IPR011992 EF-Hand_type [ SRS ] IPR011992 EF-Hand_type [ EBI ] |
| Interpro | IPR002048 EF_hand_Ca_bd [ SRS ] IPR002048 EF_hand_Ca_bd [ EBI ] |
| Interpro | IPR000261 EPS15_homology [ SRS ] IPR000261 EPS15_homology [ EBI ] |
| Interpro | IPR003903 UIM [ SRS ] IPR003903 UIM [ EBI ] |
| CluSTr | P42566 |
| Pfam | PF00036 efhand [ SRS ] PF00036 efhand [ Sanger ] pfam00036 [ NCBI-CDD ] |
| Smart | SM00054 EFh [EMBL] |
| Smart | SM00027 EH [EMBL] |
| Smart | SM00726 UIM [EMBL] |
| Blocks | P42566 |
| PDB | 1C07 [ SRS ] 1C07 [ PdbSum ], 1C07 [ IMB ] 1C07 [ RSDB ] |
| PDB | 1EH2 [ SRS ] 1EH2 [ PdbSum ], 1EH2 [ IMB ] 1EH2 [ RSDB ] |
| PDB | 1F8H [ SRS ] 1F8H [ PdbSum ], 1F8H [ IMB ] 1F8H [ RSDB ] |
| PDB | 1FF1 [ SRS ] 1FF1 [ PdbSum ], 1FF1 [ IMB ] 1FF1 [ RSDB ] |
| PDB | 2IV9 [ SRS ] 2IV9 [ PdbSum ], 2IV9 [ IMB ] 2IV9 [ RSDB ] |
| PDB | 2JXC [ SRS ] 2JXC [ PdbSum ], 2JXC [ IMB ] 2JXC [ RSDB ] |
| HPRD | 08968 |
| Protein Interaction databases |
|---|
| DIP | P42566 |
| IntAct | P42566 |
| Polymorphism : SNP, mutations, diseases |
|---|
| OMIM | 600051 [ map ] |
| GENECLINICS | 600051 |
| SNP | EPS15 [dbSNP-NCBI] |
| SNP | NM_001981 [SNP-NCI] |
| SNP | EPS15 [GeneSNPs - Utah] EPS15] [HGBASE - SRS] |
| HAPMAP | EPS15 [HAPMAP] |
| COSMIC | EPS15 [Somatic mutation (COSMIC-CGP-Sanger)] |
| TICdb | EPS15 [Translocation breakpoints In Cancer] |
| HGMD | EPS15 |
| General knowledge |
|---|
| Family Browser | EPS15 [UCSC Family Browser] |
| SOURCE | NM_001981 |
| SMD | Hs.83722 |
| SAGE | Hs.83722 |
| GO | calcium ion binding [Amigo] calcium ion binding |
| GO | protein binding [Amigo] protein binding |
| GO | cytoplasm [Amigo] cytoplasm |
| GO | cytosol [Amigo] cytosol |
| GO | plasma membrane [Amigo] plasma membrane |
| GO | coated pit [Amigo] coated pit |
| GO | epidermal growth factor receptor signaling pathway [Amigo] epidermal growth factor receptor signaling pathway |
| GO | cell proliferation [Amigo] cell proliferation |
| GO | vesicle organization and biogenesis [Amigo] vesicle organization and biogenesis |
| BIOCARTA | Endocytotic role of NDK, Phosphins and Dynamin [Genes] |
| PubGene | EPS15 |
| TreeFam | EPS15 |
| CTD | 2060 [Comparative ToxicoGenomics Database] |
| Other databases |
|---|
| Probes |
|---|
| Probe | Cancer Cytogenetics (Bari) |
| Probe | EPS15 Related clones (RZPD - Berlin) |
| PubMed |
|---|
| PubMed | 55 Pubmed reference(s) in LocusLink |
| eps15, a novel tyrosine kinase substrate, exhibits transforming activity. |
| Fazioli F, Minichiello L, Matoskova B, Wong WT, Di Fiore PP |
| Molecular and cellular biology. 1993 ; 13 (9) : 5814-5828. |
| PMID 7689153 |
| |
| A novel gene, AF-1p, fused to HRX in t(1;11)(p32;q23), is not related to AF-4, AF-9 nor ENL. |
| Bernard OA, Mauchauffe M, Mecucci C, Van den Berghe H, Berger R |
| Oncogene. 1994 ; 9 (4) : 1039-1045. |
| PMID 8134107 |
| |
| Molecular basis of 11q23 rearrangements in hematopoietic malignant proliferations. |
| Bernard OA, Berger R |
| Genes, chromosomes & cancer. 1995 ; 13 (2) : 75-85. |
| PMID 7542910 |
| |
| 11q23 rearrangements in acute leukemia. |
| Rubnitz JE, Behm FG, Downing JR |
| Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 1996 ; 10 (1) : 74-82. |
| PMID 8558942 |
| |
| Eps15 is a component of clathrin-coated pits and vesicles and is located at the rim of coated pits. |
| Tebar F, Sorkina T, Sorkin A, Ericsson M, Kirchhausen T |
| The Journal of biological chemistry. 1996 ; 271 (46) : 28727-28730. |
| PMID 8910509 |
| |
| Chromosome abnormalities in leukaemia: the 11q23 paradigm. |
| Young BD, Saha V |
| Cancer surveys. 1996 ; 28 : 225-245. |
| PMID 8977038 |
| |
| Pan1p, yeast eps15, functions as a multivalent adaptor that coordinates protein-protein interactions essential for endocytosis. |
| Wendland B, Emr SD |
| The Journal of cell biology. 1998 ; 141 (1) : 71-84. |
| PMID 9531549 |
| |
