Atlas of Genetics and Cytogenetics in Oncology and Haematology
MLLT4 (myeloid/lymphoid or mixed-lineage leukemia (trithorax); translocated to, 4)
| Identity |
| Other names | AF6 (ALL1 fused gene from chromosome 6) |
| MLLT4 (myeloid/lymphoid leukemia translocated to, n 4) | |
| HGNC (Hugo) | MLLT4 |
| Location | 6q27 |
| Location_base_pair | Starts at 167970520 and ends at 168108564 bp from pter ( according to hg18-Mar_2006) [Mapping] |
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| AF6 (6q27) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics. Laboratories willing to validate the probes are welcome : contact rocchi@biologia.uniba.it | |
| DNA/RNA |
| Transcription | 8 kb mRNA; coding sequence: 4.8 kb |
| Protein |
| Description | 1612 amino acids; contains a GLGF motif, which may have a role in membrane/cytoskeleton relations |
| Expression | widely expressed |
| Localisation | cytoplasmic |
| Function | may be involved in molecular transport system; signal transduction |
| Homology | cno (drosophila) |
| Implicated in |
| Entity | t(6;11)(q27;q23)/ANLL --> MLL/AF6 |
| Disease | M4/M5 ANLL mainly |
| Prognosis | poor |
| Cytogenetics | may be overlooked; +8 is a frequent additional chromosome anomaly |
| Hybrid/Mutated Gene | 5' MLL- 3' AF6 |
| Abnormal Protein | NH2-term MLL (with the AT hook and DNA binding motifs) and most of AF6 |
| External links |
| Bibliography |
| Cloning of the ALL-1 fusion partner, the AF-6 gene, involved in acute myeloid leukemias with the t(6;11) chromosome translocation. |
| Prasad R, Gu Y, Alder H, Nakamura T, Canaani O, Saito H, Huebner K, Gale RP, Nowell PC, Kuriyama K |
| Cancer research. 1993 ; 53 (23) : 5624-5628. |
| PMID 8242616 |
| Chromosome abnormalities in leukaemia: the 11q23 paradigm. |
| Young BD, Saha V |
| Cancer surveys. 1996 ; 28 : 225-245. |
| PMID 8977038 |
| Molecular basis of 11q23 rearrangements in hematopoietic malignant proliferations. |
| Bernard OA, Berger R |
| Genes, chromosomes & cancer. 1995 ; 13 (2) : 75-85. |
| PMID 7542910 |
| 11q23 rearrangements in acute leukemia. |
| Rubnitz JE, Behm FG, Downing JR |
| Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 1996 ; 10 (1) : 74-82. |
| PMID 8558942 |
| REVIEW articles | automatic search in PubMed |
| Last year publications | automatic search in PubMed |
| Contributor(s) |
| Written | 12-1997 | Jean-Loup Huret |
| Citation |
| This paper should be referenced as such : |
| Huret JL . MLLT4 (myeloid/lymphoid or mixed-lineage leukemia (trithorax); translocated to, 4). Atlas Genet Cytogenet Oncol Haematol. December 1997 . URL : http://AtlasGeneticsOncology.org/Genes/AF6.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Sat Feb 6 13:40:37 CET 2010 |
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