ALEX1 (arm protein lost in epithelial cancers, X chromosome, 1)

Identity

Hugo	ARMCX1
Location	Xq22.1

DNA/RNA

Description	spans 4.2 kb; 4 exons; exon 4 is the only coding exon
Transcription	cDNA: 2141 bp

Protein

Description	453 amino acids, 49 kDa.; contains a transmembrane domain in N term, an ATP/GTP binding site, 2 arm (armadillo) repeats, and potential phosphorylation sites
Expression	wide in normal tissues, except leucocytes; lost or significantly reduced in carcinomas
Homology	with ALEX2 and ALEX3

External links

	Nomenclature
Hugo	ARMCX1
GDB	ARMCX1
Entrez_Gene	ARMCX1  51309  armadillo repeat containing, X-linked 1
	Cards
Atlas	ALEX1Xq22ID477
GeneCards	ARMCX1
Ensembl	ARMCX1 [Search_View]   ENSG00000126947 [Gene_View]
Genatlas	ARMCX1
GeneLynx	ARMCX1
eGenome	ARMCX1
euGene	51309
	Genomic and cartography
GoldenPath	ARMCX1  -  Xq22.1   chrX:100692170-100696329 +  Xq21.33-q22.2    (hg18-Mar_2006)
Ensembl	ARMCX1 - Xq21.33-q22.2 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	ARMCX1
	Gene and transcription
Genbank	AB039670 [ ENTREZ ]
Genbank	AF248963 [ ENTREZ ]
Genbank	AK074785 [ ENTREZ ]
Genbank	AK222578 [ ENTREZ ]
Genbank	BC002691 [ ENTREZ ]
RefSeq	NM_016608 [ SRS ]    NM_016608 [ ENTREZ ]
RefSeq	AC_000066 [ SRS ]    AC_000066 [ ENTREZ ]
RefSeq	NC_000023 [ SRS ]    NC_000023 [ ENTREZ ]
RefSeq	NT_011651 [ SRS ]    NT_011651 [ ENTREZ ]
RefSeq	NW_927715 [ SRS ]    NW_927715 [ ENTREZ ]
AceView	ARMCX1 AceView - NCBI
Unigene	Hs.9728 [ SRS ]    Hs.9728 [ NCBI ]     HS9728 [ spliceNest ]
Fast-db	12446 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	Q9P291 [ SRS]    Q9P291 [ EXPASY ]     Q9P291 [ INTERPRO ]
Prosite	PS50176 ARM_REPEAT [ SRS ]    PS50176 ARM_REPEAT [ Expasy ]
Interpro	IPR011989 ARM-like [ SRS ]    IPR011989 ARM-like [ EBI ]
Interpro	IPR000225 Armadillo [ SRS ]    IPR000225 Armadillo [ EBI ]
Interpro	IPR006911 DUF634 [ SRS ]    IPR006911 DUF634 [ EBI ]
CluSTr	Q9P291
Pfam	PF04826 DUF634 [ SRS ]    PF04826 DUF634 [ Sanger ]    pfam04826 [ NCBI-CDD ]
Blocks	Q9P291
HPRD	02292
	Protein Interaction databases
DIP	Q9P291
IntAct	Q9P291
	Polymorphism : SNP, mutations, diseases
OMIM	300362    [ map ]
GENECLINICS	300362
SNP	ARMCX1 [dbSNP-NCBI]
SNP	NM_016608 [SNP-NCI]
SNP	ARMCX1 [GeneSNPs - Utah]  ARMCX1] [HGBASE - SRS]
HAPMAP	ARMCX1 [HAPMAP]
COSMIC	ARMCX1 [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	ARMCX1
	General knowledge
Family Browser	ARMCX1 [UCSC Family Browser]
SOURCE	NM_016608
SMD	Hs.9728
SAGE	Hs.9728
GO	binding [Amigo]  binding
GO	membrane [Amigo]  membrane
GO	integral to membrane [Amigo]  integral to membrane
PubGene	ARMCX1
TreeFam	ARMCX1
	Other databases
	Probes
Probe	ARMCX1 Related clones (RZPD - Berlin)
	PubMed
PubMed	8 Pubmed reference(s) in LocusLink

Bibliography

ALEX1, a novel human armadillo repeat protein that is expressed differentially in normal tissues and carcinomas.

Kurochkin IV, Yonemitsu N, Funahashi SI, Nomura H

Biochemical and biophysical research communications. 2001 ; 280 (1) : 340-347.

PMID 11162520

REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	07-2003	Jean-Loup Huret, Sylvie Senon

Citation

This paper should be referenced as such :

Huret JL, Senon S . ALEX1 (arm protein lost in epithelial cancers, X chromosome, 1). Atlas Genet Cytogenet Oncol Haematol. July 2003 . URL : http://AtlasGeneticsOncology.org/Genes/ALEX1Xq22ID477.html

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Mon May 12 18:01:29 2008