Atlas of Genetics and Cytogenetics in Oncology and Haematology

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   
X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

ARMCX3 (arm protein lost in epithelial cancers, X chromosome, 3)

Identity

Other namesALEX3 (arm protein lost in epithelial cancers, X chromosome, 3)
HGNC (Hugo) ARMCX3
Location Xq22.1
Location_base_pair Starts at 100764776 and ends at 100769487 bp from pter ( according to hg18-Mar_2006)  [Mapping]

DNA/RNA

Description spans 3.3 kb
Transcription transcript: 2.0 kb

Protein

Description 379 amino acids, 42.5 kDa; contains a transmembrane domain in N term, and a arm (armadillo) repeat
Homology with ALEX1 and ALEX2

Mutations

Note may be involved in tumorigenesis, but further studies are needed

External links

Nomenclature
HGNC (Hugo)ARMCX3   24065
Entrez_Gene (NCBI)ARMCX3  51566  armadillo repeat containing, X-linked 3
Cards
AtlasALEX3Xq22ID479
GeneCards (Weizmann)ARMCX3
Ensembl (Hinxton)ENSG00000102401 [Gene_View]  ARMCX3 [Vega]
AceView (NCBI)ARMCX3
Genatlas (Paris)ARMCX3
euGene (Indiana)51566
SOURCE (Stanford)NM_016607 NM_177947 NM_177948
Gene Expression (Array Express) ENSG00000102401
Genomic and cartography
GoldenPath (UCSC)ARMCX3  -  Xq22.1   chrX:100764776-100769487 +  Xq21.33-q22.2   [Description]    (hg18-Mar_2006)
EnsemblARMCX3 - Xq21.33-q22.2 [CytoView]
Mapping of homologs : NCBIARMCX3 [Mapview]
OMIM300364   
Gene and transcription
Gene : Genbank (Entrez)AB039669 AF211175 AK222655 AK291225 AL708980
Reference sequence (RefSeq transcript) :SRSNM_016607 NM_177947 NM_177948
Reference transcript : EntrezNM_016607 NM_177947 NM_177948
RefSeq genomic : SRSAC_000066 AC_000155 NC_000023 NG_013222 NT_011651 NW_001842387 NW_927715
RefSeq genomic : EntrezAC_000066 AC_000155 NC_000023 NG_013222 NT_011651 NW_001842387 NW_927715
Consensus coding sequences : CCDS NCBIARMCX3
Cluster EST : UnigeneHs.592225 [ SRS ] Hs.592225 [ NCBI ]
Alternative Splicing : Fast-db (Paris)12458
Protein : pattern, domain, 3D structure
Protein : UniProt/SwissProtQ9UH62 (SRS) Q9UH62 (Expasy) Q9UH62 (Uniprot)
With graphics : InterProQ9UH62
Splice isoforms : VarSplice FASTAQ9UH62(VarSplice FASTA)
Domaine pattern : Prosite (SRS)ARM_REPEAT (PS50176)   
Domain pattern : Prosite (Expaxy)ARM_REPEAT (PS50176)   
Domains : Interpro (SRS)ARM-like    ARM-type_fold    Armadillo    DUF634   
Domains : Interpro (EBI)ARM-like    ARM-type_fold    Armadillo    DUF634   
Related proteins : CluSTrQ9UH62
Domain families : Pfam SRSDUF634 (PF04826)   
Domain families : Pfam SangerDUF634 (PF04826)   
Domain families : Pfam NCBIpfam04826   
Blocks (Seattle)Q9UH62
Crystal structure of protein : PDB SRS
Crystal structure of protein : PDBSum
Crystal structure of protein : IMB
Crystal structure of protein : PDB RSDB
HPRD02294
Protein Interaction databases
DIP (DOE-UCLA)Q9UH62
IntAct (EBI)Q9UH62
Polymorphism : SNP, mutations, diseases
Single Nucleotide Polymorphism (SNP) : dbSNP NCBIARMCX3
SNP : GeneSNP UtahARMCX3
SNP : HGBaseARMCX3
Genetic variants : HAPMAPARMCX3
Somatic Mutations in Cancer : COSMICARMCX3 
Mutations and Diseases : HGMDARMCX3
Hereditary diseases : OMIM300364   
Hereditary diseases : GENETests300364   
Diseases : Genetic AssociationARMCX3
General knowledge
Homologs : HomoloGeneARMCX3
Homology/Alignments : Family Browser UCSCARMCX3
Phylogenetic Trees/Animal Genes : TreeFamARMCX3
Chemical/Protein Interactions : CTD51566
Keywords Ontology : AmiGObinding  membrane  integral to membrane  
Keywords Ontology : EGO-EBIbinding  membrane  integral to membrane  
Pathways : BIOCARTA
Pathways : KEGG
Other databases
Probes
Probes : ImagenesARMCX3 Related clones (RZPD - Berlin)
Literature
PubMed13 Pubmed reference(s) in Entrez
PubGeneARMCX3

Bibliography

ALEX1, a novel human armadillo repeat protein that is expressed differentially in normal tissues and carcinomas.
Kurochkin IV, Yonemitsu N, Funahashi SI, Nomura H
Biochemical and biophysical research communications. 2001 ; 280 (1) : 340-347.
PMID 11162520
 
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written07-2003Jean-Loup Huret, Sylvie Senon

Citation

This paper should be referenced as such :
Huret JL, Senon S . ARMCX3 (arm protein lost in epithelial cancers, X chromosome, 3). Atlas Genet Cytogenet Oncol Haematol. July 2003 .
URL : http://AtlasGeneticsOncology.org/Genes/ALEX3Xq22ID479.html

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Feb 27 10:48:22 CET 2010
Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.