ALO17 (ALK lymphoma oligomerization partner on chromosome 17)

Identity

HGNC	KIAA1618
Location	17q25

DNA/RNA

Transcription

alternate spicing; 5185 and 5332 bp cDNA

Protein

Description

1550 and 1599 amino acids if the sequence is complete; putative zinc finger in the N term, and AraC motif in the C term

Implicated in

Entity	Anaplasic large cell lymphoma (ALCL) with t(2;17)(p23;q25) --> ALK- ALO17
Disease	ALCL are high grade non Hodgkin lymphomas; ALK+ ALCL are ALCL where ALK is involved in a fusion gene; ALK+ ALCL represent 50 to 60 % of ALCL cases (they are CD30+, ALK+;); belong to the "cytoplasmic ALK+" subset.
Prognosis	Althouth presenting as a high grade tumour, a 80% five yr survival is associated with this anomaly
Hybrid/Mutated Gene	5' ALO17 - 3' ALK
Abnormal Protein	NH2 ALO17 - COOH ALK

External links

	Nomenclature
HGNC	KIAA1618   19047
Entrez_Gene	KIAA1618  57714  KIAA1618
	Cards
Atlas	ALO17ID480
GeneCards	KIAA1618
Ensembl	KIAA1618 [Search_View]   ENSG00000180843 [Gene_View]
Genatlas	KIAA1618
GeneLynx	KIAA1618
eGenome	KIAA1618
euGene	57714
	Genomic and cartography
GoldenPath	KIAA1618  -  17q25   chr17:75849262-75909857 +  17q25.3   [Description]    (hg18-Mar_2006)
Ensembl	KIAA1618 - 17q25.3 [CytoView]
NCBI	Mapview
HomoloGene	KIAA1618
	Gene and transcription
Genbank	AB046838 [ ENTREZ ]
Genbank	AF397204 [ ENTREZ ]
Genbank	AF397205 [ ENTREZ ]
Genbank	AK023113 [ ENTREZ ]
Genbank	AL832920 [ ENTREZ ]
RefSeq	NM_020954 [ SRS ]    NM_020954 [ ENTREZ ]
RefSeq	AC_000149 [ SRS ]    AC_000149 [ ENTREZ ]
RefSeq	NC_000017 [ SRS ]    NC_000017 [ ENTREZ ]
RefSeq	NT_024871 [ SRS ]    NT_024871 [ ENTREZ ]
RefSeq	NW_001838457 [ SRS ]    NW_001838457 [ ENTREZ ]
AceView	KIAA1618 AceView - NCBI
Unigene	Hs.514554 [ SRS ]    Hs.514554 [ NCBI ]     HS514554 [ spliceNest ]
Fast-db	15480 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	Q9H932 [ SRS]    Q9H932 [ EXPASY ]     Q9H932 [ INTERPRO ]     Q9H932 [ UNIPROT ]
CluSTr	Q9H932
Blocks	Q9H932
HPRD	11156
	Protein Interaction databases
DIP	Q9H932
IntAct	Q9H932
	Polymorphism : SNP, mutations, diseases
SNP	KIAA1618 [dbSNP-NCBI]
SNP	NM_020954 [SNP-NCI]
SNP	KIAA1618 [GeneSNPs - Utah]  KIAA1618] [HGBASE - SRS]
HAPMAP	KIAA1618 [HAPMAP]
COSMIC	KIAA1618 [Somatic mutation (COSMIC-CGP-Sanger)]
TICdb	KIAA1618 [Translocation breakpoints In Cancer]
HGMD	KIAA1618
	General knowledge
Family Browser	KIAA1618 [UCSC Family Browser]
SOURCE	NM_020954
SMD	Hs.514554
SAGE	Hs.514554
PubGene	KIAA1618
TreeFam	KIAA1618
CTD	57714 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	KIAA1618 Related clones (RZPD - Berlin)
	PubMed
PubMed	5 Pubmed reference(s) in LocusLink

Bibliography

Identification of novel fusion partners of ALK, the anaplastic lymphoma kinase, in anaplastic large-cell lymphoma and inflammatory myofibroblastic tumor.

Cools J, Wlodarska I, Somers R, Mentens N, Pedeutour F, Maes B, De Wolf-Peeters C, Pauwels P, Hagemeijer A, Marynen P

Genes, chromosomes & cancer. 2002 ; 34 (4) : 354-362.

PMID 12112524

REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	08-2003	Jean-Loup Huret, Sylvie Senon

Citation

This paper should be referenced as such :

Huret JL, Senon S . ALO17 (ALK lymphoma oligomerization partner on chromosome 17). Atlas Genet Cytogenet Oncol Haematol. August 2003 . URL : http://AtlasGeneticsOncology.org/Genes/ALO17ID480.html

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Mon Aug 11 21:12:04 2008