Atlas of Genetics and Cytogenetics in Oncology and Haematology
ATF1 (activating transcription factor 1)
| Identity |
| Other names | TREB36 |
| HGNC (Hugo) | ATF1 |
| Location | 12q13 |
| Location_base_pair | Starts at 49444086 and ends at 49501174 bp from pter ( according to hg18-Mar_2006) [Mapping] |
| DNA/RNA |
| Transcription | 816 bp mRNA |
| Protein |
| Description | 271 amino acids; possess a basic motif and a leucine-zipper; dimerisation with other ATF family members (e.g. ATF-1 homodimers and ATF-1/CREB heterodimers) |
| Localisation | nuclear |
| Function | DNA binding protein, binds the consensus sequence: 5'GTGACGT(A/C)(A/G)-3'; cAMP-inducible transcription factor (cAMP-responsive enhancer-binding protein (CRE), like CREB |
| Homology | members of the CREB protein family |
| Implicated in |
| Entity | malignant melanoma of soft parts |
| Disease | very rare neuroectodermal tumour |
| Prognosis | very poor |
| Cytogenetics | characterised by the translocation t(12;22)(q13;q12) |
| Hybrid/Mutated Gene | 5' EWSR1- 3' ATF1 |
| Abnormal Protein | the chimaeric protein is composed of the N-terminal domain of EWS linked to the bZIP domain of ATF-1 |
| Oncogenesis | binds to ATF sites present in cAMP-responsive promoters via the ATF1 bZIP domain and activates transcription constitutively, dependent on the activation domain (EAD) present in EWSR1 |
| Breakpoints |
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| External links |
| Bibliography |
| Multiple cDNA clones encoding nuclear proteins that bind to the tax-dependent enhancer of HTLV-1: all contain a leucine zipper structure and basic amino acid domain. |
| Yoshimura T, Fujisawa J, Yoshida M |
| The EMBO journal. 1990 ; 9 (8) : 2537-2542. |
| PMID 2196176 |
| The cAMP-regulated enhancer-binding protein ATF-1 activates transcription in response to cAMP-dependent protein kinase A. |
| Rehfuss RP, Walton KM, Loriaux MM, Goodman RH |
| The Journal of biological chemistry. 1991 ; 266 (28) : 18431-18434. |
| PMID 1655749 |
| EWS and ATF-1 gene fusion induced by t(12;22) translocation in malignant melanoma of soft parts. |
| Zucman J, Delattre O, Desmaze C, Epstein AL, Stenman G, Speleman F, Fletchers CD, Aurias A, Thomas G |
| Nature genetics. 1993 ; 4 (4) : 341-345. |
| PMID 8401579 |
| ATF1 and CREB trans-activate a cell cycle regulated histone H4 gene at a distal nuclear matrix associated promoter element. |
| Guo B, Stein JL, van Wijnen AJ, Stein GS |
| Biochemistry. 1997 ; 36 (47) : 14447-14455. |
| PMID 9398163 |
| The EWS/ATF1 fusion protein contains a dispersed activation domain that functions directly. |
| Pan S, Ming KY, Dunn TA, Li KK, Lee KA |
| Oncogene. 1998 ; 16 (12) : 1625-1631. |
| PMID 9569031 |
| REVIEW articles | automatic search in PubMed |
| Last year publications | automatic search in PubMed |
| Contributor(s) |
| Written | 11-1999 | Jean-Loup Huret |
| Citation |
| This paper should be referenced as such : |
| Huret JL . ATF1 (activating transcription factor 1). Atlas Genet Cytogenet Oncol Haematol. November 1999 . URL : http://AtlasGeneticsOncology.org/Genes/ATF1ID81.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Sat Feb 6 13:45:17 CET 2010 |
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