Atlas of Genetics and Cytogenetics in Oncology and Haematology

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   
X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

CAGE1 (cancer-associated gene-1)

Identity

Other namesCAGE-1 (cancer-associated gene-1)
HGNC (Hugo) CAGE1
Location 6p24.3
Location_base_pair Starts at 7271886 and ends at 7334941 bp from pter ( according to hg18-Mar_2006)  [Mapping]

DNA/RNA

Description spans 63 kb; 11 exons; ORF: 1920 bp

Protein

Description 639 amino acids;73 kDa; carry 2 consensus glycosylation sites, 10 PKC dependent phosphorylation sites
Expression testis-restricted in normal tissues; wide/high expression in various cancer tissues (lung, cervix, stomach) CAG1 is a probable member of the cancer/testis antigen family
Localisation mainly nuclear
Function may be involved in signaling pathway
Homology with monkey genes with testis specific expression

Mutations

Somatic may be associated with tumor progression .

External links

Nomenclature
HGNC (Hugo)CAGE1   21622
Entrez_Gene (NCBI)CAGE1  285782  cancer antigen 1
Cards
AtlasCAG1ID475
GeneCards (Weizmann)CAGE1
Ensembl (Hinxton)ENSG00000164304 [Gene_View]  CAGE1 [Vega]
AceView (NCBI)CAGE1
Genatlas (Paris)CAGE1
euGene (Indiana)285782
SOURCE (Stanford)NM_001170692 NM_001170693 NM_205864
Gene Expression (Array Express) ENSG00000164304
Genomic and cartography
GoldenPath (UCSC)CAGE1  -  6p24.3   chr6:7271886-7334941 -  6p24.3   [Description]    (hg18-Mar_2006)
EnsemblCAGE1 - 6p24.3 [CytoView]
Mapping of homologs : NCBICAGE1 [Mapview]
OMIM608304   
Gene and transcription
Gene : Genbank (Entrez)AF414185 AK097760 BC026188 BC026194 BC033545
Reference sequence (RefSeq transcript) :SRSNM_001170692 NM_001170693 NM_205864
Reference transcript : EntrezNM_001170692 NM_001170693 NM_205864
RefSeq genomic : SRSAC_000049 AC_000138 NC_000006 NT_007592 NW_001838973 NW_922984
RefSeq genomic : EntrezAC_000049 AC_000138 NC_000006 NT_007592 NW_001838973 NW_922984
Consensus coding sequences : CCDS NCBICAGE1
Cluster EST : UnigeneHs.721486 [ SRS ] Hs.721486 [ NCBI ]
Alternative Splicing : Fast-db (Paris)1908
Protein : pattern, domain, 3D structure
Protein : UniProt/SwissProtQ8TC20 (SRS) Q8TC20 (Expasy) Q8TC20 (Uniprot)
With graphics : InterProQ8TC20
Splice isoforms : VarSplice FASTAQ8TC20(VarSplice FASTA)
Related proteins : CluSTrQ8TC20
Domain families : Pfam SRS
Domain families : Pfam Sanger
Domain families : Pfam NCBI
Blocks (Seattle)Q8TC20
Crystal structure of protein : PDB SRS
Crystal structure of protein : PDBSum
Crystal structure of protein : IMB
Crystal structure of protein : PDB RSDB
HPRD10511
Protein Interaction databases
DIP (DOE-UCLA)Q8TC20
IntAct (EBI)Q8TC20
Polymorphism : SNP, mutations, diseases
Single Nucleotide Polymorphism (SNP) : dbSNP NCBICAGE1
SNP : GeneSNP UtahCAGE1
SNP : HGBaseCAGE1
Genetic variants : HAPMAPCAGE1
Mutations and Diseases : HGMDCAGE1
Hereditary diseases : OMIM608304   
Hereditary diseases : GENETests608304   
Diseases : Genetic AssociationCAGE1
General knowledge
Homologs : HomoloGeneCAGE1
Homology/Alignments : Family Browser UCSCCAGE1
Phylogenetic Trees/Animal Genes : TreeFamCAGE1
Chemical/Protein Interactions : CTD285782
Keywords Ontology : AmiGO
Keywords Ontology : EGO-EBI
Pathways : BIOCARTA
Pathways : KEGG
Other databases
Probes
Probes : ImagenesCAGE1 Related clones (RZPD - Berlin)
Literature
PubMed8 Pubmed reference(s) in Entrez
PubGeneCAGE1

Bibliography

Identification and characterization of a novel cancer/testis antigen gene CAGE-1.
Park S, Lim Y, Lee D, Cho B, Bang YJ, Sung S, Kim HY, Kim DK, Lee YS, Song Y, Jeoung DI
Biochimica et biophysica acta. 2003 ; 1625 (2) : 173-182.
PMID 12531476
 
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written07-2003Jean-Loup Huret, Sylvie Senon

Citation

This paper should be referenced as such :
Huret JL, Senon S . CAGE1 (cancer-associated gene-1). Atlas Genet Cytogenet Oncol Haematol. July 2003 .
URL : http://AtlasGeneticsOncology.org/Genes/CAG1ID475.html

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Feb 27 10:54:27 CET 2010
Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.