CARS (cysteinyj-tRNA synthetase)

Identity

Other names	cysteine-tRNA ligase
	cysteinease-translase
HGNC	CARS
Location	11p15.5
Local_order	700 kb telomeric to NUP98

DNA/RNA

Description	The gene spans 57 kb; 22 exons; 2,5 kb cDNA
Transcription	alternate splicing

Protein

Description	748 amino acids, 85 kDa. Forms homodimers
Localisation	cytoplasmic

Implicated in

Entity	Inflammatory myofibroblastic tumors with a complex t(2;11)(p23;p15)
Disease	rare soft tissue tumour found in children and young adults
Prognosis	good prognosis
Hybrid/Mutated Gene	5' CARS - 3' ALK
Abnormal Protein	N-term CARS (606 amino acids) fused to the usual 562 C-term amino acids of ALK

External links

	Nomenclature
HGNC	CARS   1493
Entrez_Gene	CARS  833  cysteinyl-tRNA synthetase
	Cards
Atlas	CARSID484
GeneCards	CARS
Ensembl	CARS [Search_View]   ENSG00000110619 [Gene_View]
Genatlas	CARS
GeneLynx	CARS
eGenome	CARS
euGene	833
	Genomic and cartography
GoldenPath	CARS  -  11p15.5   chr11:2978735-3035247 -  11p15.5   [Description]    (hg18-Mar_2006)
Ensembl	CARS - 11p15.5 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	CARS
	Gene and transcription
Genbank	AB208814 [ ENTREZ ]
Genbank	AF288206 [ ENTREZ ]
Genbank	AF288207 [ ENTREZ ]
Genbank	AK096313 [ ENTREZ ]
Genbank	AK125503 [ ENTREZ ]
RefSeq	NM_001014437 [ SRS ]    NM_001014437 [ ENTREZ ]
RefSeq	NM_001014438 [ SRS ]    NM_001014438 [ ENTREZ ]
RefSeq	NM_001751 [ SRS ]    NM_001751 [ ENTREZ ]
RefSeq	NM_139273 [ SRS ]    NM_139273 [ ENTREZ ]
RefSeq	AC_000054 [ SRS ]    AC_000054 [ ENTREZ ]
RefSeq	AC_000143 [ SRS ]    AC_000143 [ ENTREZ ]
RefSeq	NC_000011 [ SRS ]    NC_000011 [ ENTREZ ]
RefSeq	NT_009237 [ SRS ]    NT_009237 [ ENTREZ ]
RefSeq	NW_001838018 [ SRS ]    NW_001838018 [ ENTREZ ]
RefSeq	NW_924962 [ SRS ]    NW_924962 [ ENTREZ ]
AceView	CARS AceView - NCBI
Unigene	Hs.274873 [ SRS ]    Hs.274873 [ NCBI ]     HS274873 [ spliceNest ]
Fast-db	1090 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P49589 [ SRS]    P49589 [ EXPASY ]     P49589 [ INTERPRO ]     P49589 [ UNIPROT ]
Prosite	PS00178 AA_TRNA_LIGASE_I [ SRS ]    PS00178 AA_TRNA_LIGASE_I [ Expasy ]
Interpro	IPR001412 aa-tRNA-synth_I_CS [ SRS ]    IPR001412 aa-tRNA-synth_I_CS [ EBI ]
Interpro	IPR015804 Cys-tRNA-synt_Ia_C [ SRS ]    IPR015804 Cys-tRNA-synt_Ia_C [ EBI ]
Interpro	IPR015803 Cys-tRNA-synt_Ia_N [ SRS ]    IPR015803 Cys-tRNA-synt_Ia_N [ EBI ]
Interpro	IPR002308 Cys-tRNA-synth_1a [ SRS ]    IPR002308 Cys-tRNA-synth_1a [ EBI ]
Interpro	IPR014729 Rossmann-like_a/b/a_fold [ SRS ]    IPR014729 Rossmann-like_a/b/a_fold [ EBI ]
CluSTr	P49589
Pfam	PF01406 tRNA-synt_1e [ SRS ]    PF01406 tRNA-synt_1e [ Sanger ]    pfam01406 [ NCBI-CDD ]
Blocks	P49589
HPRD	00464
	Protein Interaction databases
DIP	P49589
IntAct	P49589
	Polymorphism : SNP, mutations, diseases
OMIM	123859    [ map ]
GENECLINICS	123859
SNP	CARS [dbSNP-NCBI]
SNP	NM_001014437 [SNP-NCI]
SNP	NM_001014438 [SNP-NCI]
SNP	NM_001751 [SNP-NCI]
SNP	NM_139273 [SNP-NCI]
SNP	CARS [GeneSNPs - Utah]  CARS] [HGBASE - SRS]
HAPMAP	CARS [HAPMAP]
COSMIC	CARS [Somatic mutation (COSMIC-CGP-Sanger)]
TICdb	CARS [Translocation breakpoints In Cancer]
HGMD	CARS
	General knowledge
Family Browser	CARS [UCSC Family Browser]
SOURCE	NM_001014437
SOURCE	NM_001014438
SOURCE	NM_001751
SOURCE	NM_139273
SMD	Hs.274873
SAGE	Hs.274873
Enzyme	6.1.1.16 [ Enzyme-Expasy ]   6.1.1.16 [ Enzyme-SRS ]   6.1.1.16 [ IntEnz-EBI ]   6.1.1.16 [ BRENDA ]   6.1.1.16 [ KEGG ]   6.1.1.16 [ WIT ]
GO	tRNA binding [Amigo]  tRNA binding
GO	tRNA binding [Amigo]  tRNA binding
GO	nucleotide binding [Amigo]  nucleotide binding
GO	cysteine-tRNA ligase activity [Amigo]  cysteine-tRNA ligase activity
GO	cysteine-tRNA ligase activity [Amigo]  cysteine-tRNA ligase activity
GO	receptor activity [Amigo]  receptor activity
GO	protein binding [Amigo]  protein binding
GO	ATP binding [Amigo]  ATP binding
GO	ATP binding [Amigo]  ATP binding
GO	cytoplasm [Amigo]  cytoplasm
GO	translation [Amigo]  translation
GO	cysteinyl-tRNA aminoacylation [Amigo]  cysteinyl-tRNA aminoacylation
GO	cysteinyl-tRNA aminoacylation [Amigo]  cysteinyl-tRNA aminoacylation
GO	zinc ion binding [Amigo]  zinc ion binding
GO	ligase activity [Amigo]  ligase activity
GO	protein homodimerization activity [Amigo]  protein homodimerization activity
GO	metal ion binding [Amigo]  metal ion binding
KEGG	Cysteine metabolism
KEGG	Aminoacyl-tRNA biosynthesis
PubGene	CARS
TreeFam	CARS
CTD	833 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	CARS Related clones (RZPD - Berlin)
	PubMed
PubMed	14 Pubmed reference(s) in LocusLink

Bibliography

Identification of novel fusion partners of ALK, the anaplastic lymphoma kinase, in anaplastic large-cell lymphoma and inflammatory myofibroblastic tumor.

Cools J, Wlodarska I, Somers R, Mentens N, Pedeutour F, Maes B, De Wolf-Peeters C, Pauwels P, Hagemeijer A, Marynen P

Genes, chromosomes & cancer. 2002 ; 34 (4) : 354-362.

PMID 12112524

REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	08-2003	Jean-Loup Huret, Sylvie Senon

Citation

This paper should be referenced as such :

Huret JL, Senon S . CARS (cysteinyj-tRNA synthetase). Atlas Genet Cytogenet Oncol Haematol. August 2003 . URL : http://AtlasGeneticsOncology.org/Genes/CARSID484.html

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Mon Aug 11 21:12:42 2008