Atlas of Genetics and Cytogenetics in Oncology and Haematology

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TRIP11 (thyroid hormone receptor interactor 11)

Identity

Other namesCEV14 (clonal evolution related gene on chromosome 14)
HGNC (Hugo) TRIP11
Location 14q32
Location_base_pair Starts at 91505215 and ends at 91576570 bp from pter ( according to hg18-Mar_2006)  [Mapping]

DNA/RNA

Transcription major transcripts: 7, 9 and 10.5 kb; coding sequence: 2.2 kb

Protein

Description 729 amino acids; contains a N-term leucine zipper and a C-term putative thyroid hormone receptor interacting domain
Expression is wide; high expression in heart, muscle, pancreas; found expressed in hematopoietic cell lines
Function may be a transcriptional factor

Implicated in

Entity t(5;14)(q33;q32)/ANLL --> CEV14 - PDGFRb
Disease poorly known: 1 case of ANLL
Cytogenetics found as an additional anomaly
Hybrid/Mutated Gene 5' CEV14 - 3' PDGFRb
Abnormal Protein leucine zipper from CEV14 fused to the transmembrane domain and the Tyr kinase domain of PDGFRb
  

External links

Nomenclature
HGNC (Hugo)TRIP11   12305
Entrez_Gene (NCBI)TRIP11  9321  thyroid hormone receptor interactor 11
Cards
AtlasCEV14
GeneCards (Weizmann)TRIP11
Ensembl (Hinxton)ENSG00000100815 [Gene_View]  TRIP11 [Vega]
AceView (NCBI)TRIP11
Genatlas (Paris)TRIP11
euGene (Indiana)9321
SOURCE (Stanford)NM_004239
Gene Expression (Array Express) ENSG00000100815
Genomic and cartography
GoldenPath (UCSC)TRIP11  -  14q32   chr14:91505215-91576570 -  14q31-q32   [Description]    (hg18-Mar_2006)
EnsemblTRIP11 - 14q31-q32 [CytoView]
Mapping of homologs : NCBITRIP11 [Mapview]
OMIM604505   
Gene and transcription
Gene : Genbank (Entrez)AF007217 AF011368 AK307489 AW002857 BC002656
Reference sequence (RefSeq transcript) :SRSNM_004239
Reference transcript : EntrezNM_004239
RefSeq genomic : SRSAC_000057 AC_000146 NC_000014 NT_026437 NW_001838113 NW_925561
RefSeq genomic : EntrezAC_000057 AC_000146 NC_000014 NT_026437 NW_001838113 NW_925561
Consensus coding sequences : CCDS NCBITRIP11
Cluster EST : UnigeneHs.632339 [ SRS ] Hs.632339 [ NCBI ]
Alternative Splicing : Fast-db (Paris)4922
Protein : pattern, domain, 3D structure
Protein : UniProt/SwissProtQ15643 (SRS) Q15643 (Expasy) Q15643 (Uniprot)
With graphics : InterProQ15643
Splice isoforms : VarSplice FASTAQ15643(VarSplice FASTA)
Domaine pattern : Prosite (SRS)GRIP (PS50913)   
Domain pattern : Prosite (Expaxy)GRIP (PS50913)   
Domains : Interpro (SRS)GRIP   
Domains : Interpro (EBI)GRIP   
Related proteins : CluSTrQ15643
Domain families : Pfam SRS
Domain families : Pfam Sanger
Domain families : Pfam NCBI
Blocks (Seattle)Q15643
Crystal structure of protein : PDB SRS
Crystal structure of protein : PDBSum
Crystal structure of protein : IMB
Crystal structure of protein : PDB RSDB
HPRD05143
Protein Interaction databases
DIP (DOE-UCLA)Q15643
IntAct (EBI)Q15643
Polymorphism : SNP, mutations, diseases
Single Nucleotide Polymorphism (SNP) : dbSNP NCBITRIP11
SNP : GeneSNP UtahTRIP11
SNP : HGBaseTRIP11
Genetic variants : HAPMAPTRIP11
Somatic Mutations in Cancer : COSMICTRIP11 
Translocation Breakpoints in Cancer : TICdbTRIP11 
Mutations and Diseases : HGMDTRIP11
Hereditary diseases : OMIM604505   
Hereditary diseases : GENETests604505   
Diseases : Genetic AssociationTRIP11
General knowledge
Homologs : HomoloGeneTRIP11
Homology/Alignments : Family Browser UCSCTRIP11
Phylogenetic Trees/Animal Genes : TreeFamTRIP11
Chemical/Protein Interactions : CTD9321
Keywords Ontology : AmiGOtranscription coactivator activity  protein binding  nucleus  cytoplasm  Golgi apparatus  cytoskeleton  transcription from RNA polymerase II promoter  membrane  extrinsic to membrane  
Keywords Ontology : EGO-EBItranscription coactivator activity  protein binding  nucleus  cytoplasm  Golgi apparatus  cytoskeleton  transcription from RNA polymerase II promoter  membrane  extrinsic to membrane  
Pathways : BIOCARTA
Pathways : KEGG
Other databases
Probes
Probes : ImagenesTRIP11 Related clones (RZPD - Berlin)
Literature
PubMed20 Pubmed reference(s) in Entrez
PubGeneTRIP11

Bibliography

Fusion of the platelet-derived growth factor receptor beta to a novel gene CEV14 in acute myelogenous leukemia after clonal evolution.
Abe A, Emi N, Tanimoto M, Terasaki H, Marunouchi T, Saito H
Blood. 1997 ; 90 (11) : 4271-4277.
PMID 9373237
 
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written02-1998Jean-Loup Huret

Citation

This paper should be referenced as such :
Huret JL . TRIP11 (thyroid hormone receptor interactor 11). Atlas Genet Cytogenet Oncol Haematol. February 1998 .
URL : http://AtlasGeneticsOncology.org/Genes/CEV14.html

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indexed on : Sat Feb 6 13:39:19 CET 2010
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