TRIP11 (thyroid hormone receptor interactor 11)

Identity

Other names	CEV14 (clonal evolution related gene on chromosome 14)
HGNC	TRIP11
Location	14q32
Location_base_pair	Starts at 91505215 and ends at 91576570 bp from pter (hg18-Mar_2006).

DNA/RNA

Transcription

major transcripts: 7, 9 and 10.5 kb; coding sequence: 2.2 kb

Protein

Description	729 amino acids; contains a N-term leucine zipper and a C-term putative thyroid hormone receptor interacting domain
Expression	is wide; high expression in heart, muscle, pancreas; found expressed in hematopoietic cell lines
Function	may be a transcriptional factor

Implicated in

Entity	t(5;14)(q33;q32)/ANLL --> CEV14 - PDGFRb
Disease	poorly known: 1 case of ANLL
Cytogenetics	found as an additional anomaly
Hybrid/Mutated Gene	5' CEV14 - 3' PDGFRb
Abnormal Protein	leucine zipper from CEV14 fused to the transmembrane domain and the Tyr kinase domain of PDGFRb

External links

	Nomenclature
HGNC	TRIP11   12305
Entrez_Gene	TRIP11  9321  thyroid hormone receptor interactor 11
	Cards
Atlas	CEV14
GeneCards	TRIP11
Ensembl	TRIP11 [Search_View]   ENSG00000100815 [Gene_View]
Genatlas	TRIP11
GeneLynx	TRIP11
eGenome	TRIP11
euGene	9321
	Genomic and cartography
GoldenPath	TRIP11  -  14q32   chr14:91505215-91576570 -  14q31-q32   [Description]    (hg18-Mar_2006)
Ensembl	TRIP11 - 14q31-q32 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	TRIP11
	Gene and transcription
Genbank	AF007217 [ ENTREZ ]
Genbank	AF011368 [ ENTREZ ]
Genbank	AK307489 [ ENTREZ ]
Genbank	AW002857 [ ENTREZ ]
Genbank	BC002656 [ ENTREZ ]
RefSeq	NM_004239 [ SRS ]    NM_004239 [ ENTREZ ]
RefSeq	AC_000057 [ SRS ]    AC_000057 [ ENTREZ ]
RefSeq	AC_000146 [ SRS ]    AC_000146 [ ENTREZ ]
RefSeq	NC_000014 [ SRS ]    NC_000014 [ ENTREZ ]
RefSeq	NT_026437 [ SRS ]    NT_026437 [ ENTREZ ]
RefSeq	NW_001838113 [ SRS ]    NW_001838113 [ ENTREZ ]
RefSeq	NW_925561 [ SRS ]    NW_925561 [ ENTREZ ]
AceView	TRIP11 AceView - NCBI
Unigene	Hs.632339 [ SRS ]    Hs.632339 [ NCBI ]     HS632339 [ spliceNest ]
Fast-db	4922 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	Q15643 [ SRS]    Q15643 [ EXPASY ]     Q15643 [ INTERPRO ]     Q15643 [ UNIPROT ]
Prosite	PS50913 GRIP [ SRS ]    PS50913 GRIP [ Expasy ]
Interpro	IPR000237 GRIP [ SRS ]    IPR000237 GRIP [ EBI ]
CluSTr	Q15643
Blocks	Q15643
HPRD	05143
	Protein Interaction databases
DIP	Q15643
IntAct	Q15643
	Polymorphism : SNP, mutations, diseases
OMIM	604505    [ map ]
GENECLINICS	604505
SNP	TRIP11 [dbSNP-NCBI]
SNP	NM_004239 [SNP-NCI]
SNP	TRIP11 [GeneSNPs - Utah]  TRIP11] [HGBASE - SRS]
HAPMAP	TRIP11 [HAPMAP]
COSMIC	TRIP11 [Somatic mutation (COSMIC-CGP-Sanger)]
TICdb	TRIP11 [Translocation breakpoints In Cancer]
HGMD	TRIP11
	General knowledge
Family Browser	TRIP11 [UCSC Family Browser]
SOURCE	NM_004239
SMD	Hs.632339
SAGE	Hs.632339
GO	transcription coactivator activity [Amigo]  transcription coactivator activity
GO	protein binding [Amigo]  protein binding
GO	Golgi apparatus [Amigo]  Golgi apparatus
GO	transcription from RNA polymerase II promoter [Amigo]  transcription from RNA polymerase II promoter
GO	membrane [Amigo]  membrane
PubGene	TRIP11
TreeFam	TRIP11
CTD	9321 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	TRIP11 Related clones (RZPD - Berlin)
	PubMed
PubMed	14 Pubmed reference(s) in Entrez

Bibliography

Fusion of the platelet-derived growth factor receptor beta to a novel gene CEV14 in acute myelogenous leukemia after clonal evolution.

Abe A, Emi N, Tanimoto M, Terasaki H, Marunouchi T, Saito H

Blood. 1997 ; 90 (11) : 4271-4277.

PMID 9373237

REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	02-1998	Jean-Loup Huret

Citation

This paper should be referenced as such :

Huret JL . TRIP11 (thyroid hormone receptor interactor 11). Atlas Genet Cytogenet Oncol Haematol. February 1998 . URL : http://AtlasGeneticsOncology.org/Genes/CEV14.html

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sat Oct 11 12:49:46 2008